Medico Research Chronicles <p style="text-align: justify;"><code></code>Medico Research Chronicles (Medrech) ISSN No. <a href="">2394-3971</a>, is an official journal of Medico Edge Publications. It is a peer-reviewed, open-access journal of medical and health sciences, published on bi-monthly intervals. It publishes various manuscripts on the diverse specialization of medical, health science, and clinical research.</p> <p>Indexed by the&nbsp;&nbsp;<a href=""><strong>United States'&nbsp;NLM Catalogue, NCBI</strong></a></p> <p><strong>Medico Research Chronicles has been positively evaluated by <a href="">Index Copernicus</a>, Poland for the year 2019 and assigned an IC Value of 78.67.&nbsp;</strong></p> <p><strong>Journal is valid for publication as per MCI Guidelines. A transitory period of 2 years (Upto 2022) is given for consideration of publication.&nbsp;</strong></p> <p><strong>Academicians and Researchers interested in reviewing the article are requested to join us on Publons: <a title="Publons by Web of Science" href=""></a></strong></p> <p><strong><a href="">Click Here </a></strong>for the notification details.</p> <p>&nbsp;</p> Medico Edge Publications en-US Medico Research Chronicles 2394-3971 Factors determining change of antibiotic and prolong hospital stay in children with severe pneumonia in a tertiary care hospital, Dhaka, Bangladesh <p>Background: Pneumonia is one of the most common infections in the pediatric age group and one of the leading diagnoses that results in hospital admission for children. Severe pneumonia remains a common and serious condition worldwide. Various micro-organisms can cause pneumonia, and etiologies differ by age. Clinical manifestations vary, and diagnostic testing is frequently not standardized. Objective: To identify the factors determining the need of antibiotic change and prolong hospital stay in children Under Five Years of Age Hospitalized with Severe Pneumonia. Study design: Prospective observational cohort study. Study place and period: Dhaka Shishu (Children) Hospital, Dhaka, from December 2012 to May 2013. Study population: Children under 5 years of age admitted with severe pneumonia. Sample size: n= One Hundred Fifty included. Methods/ Procedure: All the data was collected and recorded systematically in a questionnaire and was analyzed using computer software SPSS (Statistical package for social sciences) and analysis was multivariate to find out the significant factors. Main outcome measures: Change of antibiotic and prolong hospital stay, in children Under Five Years of Age Hospitalized with Severe Pneumonia of this study. Results: The mean age was found 9.49±6.83 months with range from 2 months to 36 months and Male to female ratio was 2:1. The duration of hospital stay was &gt;5 days in almost two third (62.7%) of the patients. The mean age of the mothers was 24.67±4.19 years. Regarding study of association of different factors with prolong hospital stay it was observed that patients who needed prolong hospital stay 53.2% of them live in an overcrowded environment and 32.1% patients live in an overcrowded environment who didn`t need prolong hospital stay. Among 150 study patients, 98(65.3%) needed a change in antibiotics, 94(62.7%) patients needed more than 5 days’ hospital stay. 34.7% of patients were exclusively breast fed of those who needed a change in antibiotic and 80.8% among those who didn`t need any change. 85.7% presented with head nodding among those who needed antibiotic change, on the other hand, 19.2% with head-nodding among those who didn`t need antibiotic change. Leukocytosis was found in 57.1% and 19.2% among patients who needed a change of antibiotics and didn`t need antibiotic change respectively. In patients who needed a change of antibiotic, positive blood culture was found in 20.4% of cases and it was 0% among patients who didn`t need a change. Radiological abnormality was found in 87.8% of patients who needed antibiotic change and 42.3% in patients who didn`t need antibiotic change. Statistically significant (p&lt;0.05) factors associated with two groups of patients those who needed a change of antibiotics and those who didn`t need are overcrowding, exclusive breastfeeding, head nodding on presentation, leukocytosis, positive blood culture, and abnormal CXR. Conclusion: Children hospitalized with severe community-acquired pneumonia [as defined by World Health Organization (WHO)] who had not received exclusive breastfeeding, had stayed in overcrowded homes and had an abnormal chest radiograph were more likely to fail to respond with the primary antibiotic regimen and require change of antibiotics and prolonged hospital stay.</p> Mohammed Akter Hossan Masud Mrinal Kanti Pandit Md. Shafiul Hoque Copyright (c) 2021 Mohammed Akter Hossan Masud, Mrinal Kanti Pandit, Md. Shafiul Hoque 2021-05-05 2021-05-05 8 3 120 131 10.26838/MEDRECH.2020.8.3.499 Iron with folic acid supplemenation and birth weight in Ethiopia: Systemic review and meta-analysis <p><strong>Objective</strong>: The aim of this systemic review and meta-analysis was to examine the relationship between iron with folic acid supplementation and low birth weight in Ethiopia Previous studies on iron with folic acid supplementation and low birth weight indicated different findings. We include 24 studies in different regions of Ethiopia. We have done this study focusing on iron with folic acid supplementation.</p> <p><strong>Materials and Methods</strong> The databases searched were PUBMED and Advanced Google Scholar. on reference manager software reporting iron with folic acid supplementation and low birth weight. Three researchers have carried out the data extraction and assessed independently the articles for inclusion in the review using the risk-of-bias tool guided by the PRISMA checklist.</p> <p><strong>Results:</strong> Twenty-four observational studies involving 10989 participants, 2348 newborns have low birth weight were included. The combined effect size (OR) for low birth weight r comparing women who have an iron with folic acid supplementation versus women who did not have an iron with folic acid supplementation was 0.37 (95%CI 0.25 to 0.55), p&lt;0.00001, I2 = 91 %). There was significant heterogeneity. No publication bias was observed, women reported iron with folic acid supplementation during current pregnancy in all studies, the proportion of low birth weight among women who reported iron with folic acid supplementation during the current pregnancy was 1392 (17.85%).</p> <p><strong>Conclusions:</strong> Women who take iron with folic acid supplementation during pregnancy have a 67% decreased in delivering low birth weight newborns in Ethiopia.</p> Kaleab Tesfaye Tegegne Andualem Zenebe Abiyu Ayalew Assefa Berhanu Bifato Eleni Tesfaye Tegegne Mekibib Kassa Tessema Copyright (c) 2021 Kaleab Tesfaye Tegegne*, Andualem Zenebe, Abiyu Ayalew Assefa, Berhanu Bifato, Eleni Tesfaye Tegegne, Mekibib Kassa Tessema 2021-05-08 2021-05-08 8 3 136 148 10.26838/MEDRECH.2020.8.3.493 Emergency application of Ultra-High-Diluted-Biomedicines as Vaccine-Nationalism-Equity-Passport preventing-coronavirus-2: Developed Medical Health Clinical Research Science Technology Communications! <p>The reinfection of pandemic coronavirus-2 has been increasing day to day due to the introduction of new mutant adaptive variants, and so it has been needed urgently to protect the public health measures and individual preventive precautions must be sustained where long COVID-19 is recirculating- and causing the ‘Post-acute COVID-19 syndromes’. Initially, it has been observed that ginger is very much effective against the coronavirus-patients in the Municipality of Burdwan, West Bengal, India. But it is not always cost-effective and available enough for all. To overcome this, it has been urgently suggested to apply the different ultra-high-diluted potential-edible-medicines prepared from the rhizome, Zingiber officinale which will be cost-effective, eco-friendly, easily available, easily applicable, easily preparable, and side-effects-free any kinds of toxic free substances, against the pandemic coronavirus-2 as a policy-initiative-‘Vaccine-Nationalism-Equity-Passport’. And it is developed the “Medical-and-Clinical-Research or Medico Research Chronicles, Science, Technology, and Communication Informing the Easily Equitable, Marketable and Supply-able, etc.” which enriches the highest quality scientific information on all aspects of pharmacology and devoted to qualitative researches and up-to-date ongoing trends in the related field of medical and clinical research, which will enrich the scholars, academicians, and students every day across the world also in the new normal situation.</p> Subhas Chandra Datta Copyright (c) 2021 Subhas Chandra Datta 2021-05-11 2021-05-11 8 3 132 135 10.26838/MEDRECH.2020.8.3.497 Keeping the knife sharp! <p>Being a Surgeon, even a trainee, has been a painful experience in the ongoing pandemic days, versus the world of yesterday1. The pandemic has crippled &amp; strangulated many surgical branches due to paucity of volumes e.g., Plastic - Cosmetic Surgery, Orthopedics, Joint Replacement, Ortho-Trauma, Transplant Surgery, Elective Abdominal Surgeries like Hernia – Abdominal Wall Reconstruction, Ophthalmology, etc. are the worst affected. This article is about challenges faced by the surgeons involved in more elective surgeries and how they can &amp; should survive the current catch-22 situation.</p> Vishal Soni Krunal Soni Himanshu Soni Copyright (c) 2021 Dr. Vishal Soni, Dr. Krunal Soni, Dr. Himanshu Soni 2021-05-12 2021-05-12 8 3 149 153 10.26838/MEDRECH.2020.8.3.504 Climate change: A potential risk factor for cancer? <p>Cancer, mainly known for abnormal growth and altered cellular function is now the second prominent reason of death in the world. There are so many factors responsible for this disease and one of the major factors in climate change. The deviations of weather patterns that are definitely a result of human activities over long periods of time generally referred to as climate change. The consequences include increasing temperature, melting of ice, rising sea levels, increasing wind speed, changes in rainfall patterns, etc. Due to all these concerns, the most important resource for a healthy life– Air, Water, and Food are gets disturbed and as a result, causes several health-related problems. Previous researches related to this field also demonstrated that climate change played a critical role in cancer risk and cancer surveillance. It increases the number of carcinogens and also blocks patients’ access to cancer hospitality. Here in this article, you will get to know about the impacts of climate changes on health. Why this can be potential risk factors for cancer by focusing mainly on lung and skin cancer and about some well-known limitations that we need have to resolve in the near future. In this concern, several steps have been implicated globally but more preparedness and attentiveness are reasonable.</p> Pallab Chakraborty Copyright (c) 2021 Pallab Chakraborty 2021-05-15 2021-05-15 8 3 154 163 10.26838/MEDRECH.2020.8.3.495