Medico Research Chronicles <p style="text-align: justify;"><code></code>Medico Research Chronicles (Medrech) ISSN No. <a href="">2394-3971</a>, is an official journal of Medico Edge Publications. It is a peer-reviewed, open-access journal of medical and health sciences, published on bi-monthly intervals. It publishes various manuscripts on the diverse specialization of medical, health science, and clinical research.</p> <p>Indexed by the&nbsp;&nbsp;<a href=""><strong>United States'&nbsp;NLM Catalogue, NCBI</strong></a></p> <p><strong>Medico Research Chronicles has been positively evaluated by <a href="">Index Copernicus</a>, Poland for the year 2019 and assigned an IC Value of 78.67.&nbsp;</strong></p> <p><strong>Journal is valid for publication as per MCI Guidelines. A transitory period of 2 years (Upto 2022) is given for consideration of publication.&nbsp;</strong></p> <p><strong>Academicians and Researchers interested in reviewing the article are requested to join us on Publons: <a title="Publons by Web of Science" href=""></a></strong></p> <p><strong><a href="">Click Here </a></strong>for the notification details.</p> <p>&nbsp;</p> Medico Edge Publications en-US Medico Research Chronicles 2394-3971 Anomalies of the genetic complement and its role in C3 Glomerulopathies and development of Hemolithic Uremic Syndrome <p>Let us remember that C3 glomerulopathy is the product of an abnormal activation in the alternative complement pathway, which leads to an excessive production of active C3 and its degradation products</p> Juan Esteban Tafur Delgado Carlos Andrés Pérez Lozano Lina Marcela Ortiz Roncallo Silvia Juliana Rodríguez Pérez Amaury Gustavo López Agámez María José Álvarez Gómez Ricardo Javier Galván Zúñiga Ana María Garcés Pérez Copyright (c) 2021 Juan Esteban Tafur Delgado, Carlos Andrés Pérez Lozano, Lina Marcela Ortiz Roncallo, Silvia Juliana Rodríguez Pérez, Amaury Gustavo López Agámez, María José Álvarez Gómez, Ricardo Javier Galván Zúñiga, Ana María Garcés Pérez 2021-07-20 2021-07-20 8 4 303 304 Five-year spatiotemporal distribution of malaria in hotspot and Ivermectin mass-drug administration zone of Amhara Regional State, Ethiopia <p><strong>Objectives</strong>: Evaluate the Spatiotemporal distribution of malaria in the hotspot and Ivermectin mass-drug administration Zone of Amhara Regional State, Ethiopia. Study Design: A descriptive prevalence study design was used.</p> <p><strong>Methods:</strong> - A 25 study sources were incorporated in the survey. Purposive sampling techniques were utilized. Data were obtained by the standard format of systematic evaluation of four surveillance units from January to August 2020 through observation, document review, and interviewing surveillance officers and focal persons using a semi-structured Survey. The statistical analysis, tabular, and graphical output are generated using the open-source statistical program R.</p> <p><strong>Results:</strong> - Average report fullness and aptness were 97.9% and 96% respectively. The average annual malaria incidence rate was a decline in terms of place and time, from the year 2015 to 2019 with an average reduction rate of 5.5% and the average annual parasitic incidence rate was 52 (22-199). In 2019/2020, 43,131 malaria cases were reported in the zone. The study identifies no program-specific supportive supervision of public health emergency management and no routine data analysis and was not used for decision making.</p> <p><strong>Conclusion:</strong> This result revealed that the malaria incidence rate showed a remarkable decline. However, the annual parasitic incidence rate remains constant. This indicates that ivermectin did not affect malaria elimination. Hence, the districts and sub-city health offices should conduct regular surveillance data analysis, perform supportive supervision, avail budgets and further laboratory investigations should be done to investigate the effect of ivermectin on the parasites under laboratory conditions.</p> Chalachew Yenew Sileshi Mulatu Copyright (c) 2021 Chalachew Yenew*, Sileshi Mulatu 2021-07-21 2021-07-21 8 4 305 312