Medico Research Chronicles <p style="text-align: justify;"><code></code>Medico Research Chronicles (Medrech) ISSN No. <a href="">2394-3971</a>, is an official journal of Medico Edge Publications. It is a peer-reviewed, open-access journal of medical and health sciences, published on bi-monthly intervals. It publishes various manuscripts on the diverse specialization of medical, health science, and clinical research.</p> <p>Indexed by the&nbsp;&nbsp;<a href=""><strong>United States'&nbsp;NLM Catalogue, NCBI</strong></a></p> <p><strong>Medico Research Chronicles has been positively evaluated by <a href="">Index Copernicus</a>, Poland for the year 2019 and assigned an IC Value of 78.67.&nbsp;</strong></p> <p><strong>Journal is valid for publication as per MCI Guidelines. A transitory period of 2 years (Upto 2022) is given for consideration of publication.&nbsp;</strong></p> <p><strong>Academicians and Researchers interested in reviewing the article are requested to join us on Publons: <a title="Publons by Web of Science" href=""></a></strong></p> <p><strong><a href="">Click Here </a></strong>for the notification details.</p> <p>&nbsp;</p> Medico Edge Publications en-US Medico Research Chronicles 2394-3971 Role of pulmonary rehabilibtation in cases of healed pulmonary Tuberculosis <p><strong>Introduction</strong>: Pulmonary rehabilitation is a comprehensive intervention for patients with chronic respiratory diseases who are symptomatic and often decreased life activities Pulmonary rehabilitation reduces hospitalization among patients who have a repeated exacerbation. This study is used to assess the role of pulmonary rehabilitation in healed pulmonary tuberculosis patients.</p> <p><strong>Materials and Method:</strong> This is a hospital-based randomized case-control study, conducted in 132 clinically healed tuberculosis patients in Sarojini Naidu medical college, Agra to assess the role of pulmonary rehabilitation in healed tuberculosis patient The role of pulmonary rehabilitation in healed pulmonary tuberculosis patients is assessed by 6minute walk test and Modified Borg Scale [RPE scale]</p> <p><strong>Result:</strong> The change in decline in [PRE 6MWT] observed between the case and control group was significant [p&lt;0.5]. The change in decline in [POST 6MWT] observed between the case and control group was significant [p&lt;0.5]. Conclusion: In conclusion, pulmonary rehabilitation is a new hope for patients with healed pulmonary tuberculosis. It is a treatment that reduces dyspnea and increases activities of daily living, exercise tolerance, exercise capacity, and better quality of life.</p> Ankit Mehrotra Gajendra Vikram Singh Komal Lohchab Santosh Kumar Aravind Bhanu Pratap Pandey Achal Singh Rajeev Kumar Chauhan Copyright (c) 2020-12-09 2020-12-09 7 6 333 337 10.26838/MEDRECH.2020.7.6.463 Microorganisms detected on gloves contaminated by first year MBBS students during dissection of formalin-fixed cadavers <p><strong>Introduction</strong>: The study is done with the purpose to detect if any microorganisms are detected on the dissection of formalin-fixed cadavers which can be a potential of infection for students.</p> <p><strong>Material and Method:</strong> Students were made to do a dissection of routinely preserved cadavers using gloves. Samples from the contaminated gloves were collected and sent for culture and sensitivity.</p> <p><strong>Observation and results:</strong> A variety of microorganisms were cultured from the given samples.</p> <p><strong>Conclusion:</strong> The results indicate that cadavers fixed with formalin are a potential source of infection for students as well as faculty. This study underscores protocols to decrease cross-contamination.</p> Ashfaq Khursheed Nowsheba Copyright (c) 2021 Medico Research Chronicles 2021-01-09 2021-01-09 7 6 361 365 10.26838/MEDRECH.2020.7.6.469 Dental extractions in patients on oral or intravenous bisphosphonate therapy: A clinical dilemma <p>Dental extraction has been touted to be a potential trigger for the onset of bisphosphonate-related osteonecrosis of the jaw (BRONJ). In this article, we carry out a comprehensive discussion on the pharmacology of bisphosphonates. This article also aims to assess and outline the pathogenesis of BRONJ, the outcome of dental extractions on patients receiving bisphosphonate therapy and to draw a protocol for its prevention and management.</p> Shreyas Naik Vikas Dhupar Francis Akkara Copyright (c) 2020 Medico Research Chronicles 2020-12-03 2020-12-03 7 6 322 332 10.26838/MEDRECH.2020.7.6.460 AN Unusual case of osteoblastoma in an elderly female: A case report and a review <p>Osteoblastomas are a rare entity encountered as benign osseous tumor with propensity of occurence towards the vertebral column and long bones. Commonly occurs in young middle aged&nbsp; males with mandible as a site of predilection in facial skeleton. Differential diagnosis of osteoblastoma holds a challenge in attaining a final diagnosis. Osteoid osteoma, cementoblastoma, osteosarcoma, aggressive fibrous dysplasia, and ossifying fibroma share a similar clinical behavior, radiological and histological behavior. This article aims to report a case of osteoblastoma of an aggressive variety appearing in maxilla. It aims to gain a better understanding of clinical, histological, radiological and differential diagnosis of osteoblastoma. A review of English language literature 2006 revealed 43 previously reported cases of osteoblastoma appearing in maxilla and mandible since 1967. 16 cases including this one is added to the previous well documented review of literature by Jones where he included additional 24 cases to the previously reported 43 cases. Brief discussion and review on treatment modalities are analysed.</p> Ankita Dahiya Srinath N Umashankar D N Ashish Gupta Mahadeepa Kar Copyright (c) 2020 Medico Research Chronicles 2020-12-09 2020-12-09 7 6 338 351 10.26838/MEDRECH.2020.7.6.462 Cardio-diabetic protective effect of Telmisartan <p>The antihypertensive drugs that are being used currently were primarily designed and developed to affect cellular and biochemical mechanisms that lead to increased blood pressure and do not address the underlying contributory factors like, disordered carbohydrate and lipid metabolism that often accompanies hypertension as part of the metabolic syndrome. The metabolic syndrome eventually leads to co-morbid conditions i.e., hypertension and type 2 diabetes mellitus. Both these conditions mechanistically share the common pathophysiological pathways in people who suffer from metabolic syndrome. PPAR-γ plays an important role in regulating carbohydrate and lipid metabolism and ligands for PPAR γ can improve insulin sensitivity, reduce triglyceride levels, and decrease the risk for atherosclerosis. Telmisartan is a well-established angiotensin II type 1 receptor (AT1) blocker along with an activator of the PPARγ receptor. Telmisartan has several pharmacological properties that distinguish it from other ARBs, like, the structural resemblance with pioglitazone which is a PPARγ ligand that is approved for the treatment of type 2 diabetes. Thus, telmisartan seems to be a suitable candidate for the management of CV risk reduction in patients with atherothrombotic disease or diabetes mellitus with end-organ damage. This article will discuss the mechanistic aspect of telmisartan that supports its utility in cardiac protection along with the outcome of different clinical trials.</p> Shiladitya Nandi Sourav Nag Trinanjan Ash V Chandra Shekhar Copyright (c) 2021 Medico Research Chronicles 2021-01-12 2021-01-12 7 6 366 370 10.26838/MEDRECH.2020.7.6.461 Frenectomy: Management By Electrosurgery - A Report Of Two Cases <p>The frenum is defined as a mucous membrane fold which attaches the lip and the cheek to the alveolar mucosa, the gingiva, and the underlying periosteum. The frenum may hamper the gingival health if it is attached too closely to the gingival margin. The management of such an aberrant frenum is by performing a frenectomy/frenotomy. While performing frenectomy, conventional scalpel techniques have their own traditional drawbacks. To overcome them newer techniques like electrosurgery and lasers are increasingly used in routine periodontal practice. The present article is a report of two cases of frenectomy; first case is management of an aberrant maxillary labial frenum causing midline diastema and second case is management of an aberrant lingual frenum leading to complete ankyloglossia; both using electrosurgery. Electrosurgery has been defined as the intentional passage of high-frequency waveforms or currents through the tissues of the body to achieve a controllable surgical effect. Electrosurgery is a continuously evolving field with active research into various new applications.</p> Clarence Dias Shrish Vallabh Kamat Copyright (c) 2020-11-21 2020-11-21 7 6 312 321 10.26838/MEDRECH.2020.7.6.458 Conversion disorder presenting as intractable hiccups in middle-aged male <p>Hiccups are common and often don’t require treatment. Intractable hiccups, on the other hand, are often bothersome for the patient and require therapy. Formerly known as “psychogenic”, “functional” or “hysteria”- “conversion disorder” usually present with either or both sensory and motor function deficiencies. Common in females and having a varied presentation, conversion disorders are difficult to diagnose. When an uncommon presentation of them like intractable hiccups present in sex with a lesser predisposition, the diagnosis may be missed and not appropriately managed.</p> Manpreet Singh Gagandeep Singh Shergill Nirankar Singh Neki Copyright (c) 2020-12-13 2020-12-13 7 6 352 354 10.26838/MEDRECH.2020.7.6.465 Melioidosis: A case series from a tertiary care hospital in Assam <p>Melioidosis is sporadically reported from various parts of India. We present a case series from Assam, highlighting the varied manifestations of the disease. Three cases of culture-proven melioidosis are presented in whom Burkholderia pseudomallei were isolated from aspirate or blood. Melioidosis had a varied presentation involving multiple abscesses in the soft tissues, liver, spleen, mediastinum, and the subdural space. It presented as either acute fulminant sepsis or followed a chronic indolent course, mimicking tuberculosis. Most cases had predisposing risk factors such as diabetes and chronic alcoholism.</p> <p><em>&nbsp;</em></p> Dr Vandana Sinha Dr Anup Jyoti Dutta Dr Partha Pratim Kalita Dr Himadri Dutta Pinku Sarma Dr Pranab Barua Dr Prerit Sarma Copyright (c) 2020-12-27 2020-12-27 7 6 355 360 10.26838/MEDRECH.2020.7.6.467