Medico Research Chronicles

Score- Survey on Clindamycin and Benzoyl Peroxide Outcome in Reducing Acne by Experts

Sat, 02 Aug 2025 00:00:00 +0530

Background: Topical combination therapies are the cornerstone of acne vulgaris treatment, with clindamycin-benzoyl peroxide combinations widely prescribed for synergistic antimicrobial effects. Limited data exists on dermatology practitioners' real-world experiences and prescribing patterns with these formulations across diverse Indian populations.

Objective: To evaluate dermatology practitioners' perspectives on clindamycin-benzoyl peroxide (Clin-B) combination therapy effectiveness, safety satisfaction, prescribing patterns across acne severity levels, and antibiotic stewardship implementation.

Methods: A cross-sectional survey using the SCORE (Survey on Clinred-B's Outcome in Reducing Acne by Experts) questionnaire was conducted among dermatology practitioners across six Indian states (Maharashtra, Rajasthan, Uttar Pradesh, Gujarat, Madhya Pradesh, and Telangana). The 20-question survey assessed treatment utilization, safety satisfaction, comparative effectiveness, clinical decision-making factors, and stewardship awareness. Data were analyzed using descriptive statistics.

Results: Thirty dermatology practitioners participated, with the largest representation from Maharashtra (46.7%). High combination therapy adoption was observed (66.7% using in >50% of patients). Safety satisfaction was universal (100% satisfied; 80% very satisfied). Treatment preferences demonstrated clear severity stratification: mild acne 40%, moderate 50%, moderately severe 56.7%, and severe acne 70% preferred Clin-B. Perfect antibiotic stewardship awareness was evident (100% agreement on avoiding monotherapy). Practitioners preferred once-daily night-time dosing (66.7%) and rated Clin-B favorably in comparative effectiveness assessments (73.3% versus clindamycin-adapalene; 66.7% versus adapalene-benzoyl peroxide).

Conclusion: Dermatology practitioners demonstrate strong confidence in Clin-B therapy with evidence-based, severity-stratified prescribing (40-70% preference increase). Universal safety satisfaction and perfect stewardship compliance indicate successful resistance prevention implementation. Results provide real-world validation supporting current guidelines recommending combination therapy as first-line acne treatment.

Assessment of Implant Stability in Direct and Indirect Sinus Lift Procedure - A Systematic Review and Meta-Analysis

Nikita R Kendre, Rizwan M Sanadi, Priyanka D Khandekar, Renuka S Adbol — Wed, 06 Aug 2025 00:00:00 +0530

Background and Objective : The sinus lift procedure, also known as maxillary sinus augmentation, aims to augment the bone volume in the maxillary sinus region, facilitating the placement of dental implants with adequate support and stability. The direct sinus lift procedure involves accessing the maxillary sinus through a lateral window approach, followed by elevation of the sinus membrane and placement of bone graft materials. The indirect sinus lift technique involves the use of osteotomes or hydraulic pressure devices to elevate the sinus floor, creating space for bone graft materials without the need for an extensive surgical window. The objective is to systematically review the existing scientific literature in providing a comprehensive, quantitative analysis on effectiveness between direct sinus lift and indirect sinus lift procedure for implant stability.

Methods: Review was adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines 2020 and registered in PROSPERO – CRD42024530982. Electronic databases were searched for studies evaluating the effectiveness between direct sinus lift and indirect sinus lift procedure for implant stability and reporting outcomes in terms of overall mean increase in bone height and development of pain, gingival inflammation and swelling. Quality assessment of included studies was evaluated through Cochrane risk of bias (ROB)-2 tool. The standardized mean difference (SMD) and risk ratio (RR) was used as summary statistic measure with random effect model and p value <0.05 as statistically significant through Review manager (RevMan) version 5.3.

Sculpting Soft Tissue with Diode Laser: A Prerequisite for Implant Success- A Case Report

Nikita R Kendre, Rizwan M Sanadi, Ayushya Warang-Varty, Vivek V Pathak — Fri, 08 Aug 2025 00:00:00 +0530

Introduction: Inadequate vestibular depth and insufficient attached gingiva can hinder plaque control and compromise long-term implant success. This case demonstrates the use of diode laser-assisted vestibuloplasty to optimize soft tissue conditions prior to implant placement.

Case Presentation: A 44-year-old male presented with missing mandibular anterior teeth and reported difficulty maintaining oral hygiene. Clinical examination revealed mucosal scarring and shallow vestibule due to previous faulty suturing, along with inadequate attached gingiva. Diode laser- assisted vestibuloplasty was planned to enhance soft tissue dimensions.

Management & Outcome: A horizontal laser incision at the mucogingival junction was performed without suturing. Healing was uneventful, and vestibular depth increased from 2 mm to 5 mm within 14 days. Following complete soft tissue healing, three dental implants were placed, and final prosthetic rehabilitation was completed after three months, restoring optimal function and aesthetics.

Conclusion: Diode laser-assisted vestibuloplasty is an effective, minimally invasive technique to improve soft tissue architecture, enabling successful implant placement and long-term peri-implant health.