Association of Vitamin B12 with Gestational Diabetes Mellitus

  • Dr. Nusrat Jahan Khan MCPS, DGO, MS, Junior Consultant, Department of Obstetrics and Gynaecology, Madhabpur Upazila Health Complex, Habiganj, Bangladesh
  • Dr. Begum Nasrin FCPS, MS, Professor, Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
  • Dr. Saila SharminTithi Junior Consultant, Department of Obstetrics and Gynaecology, Abhoynagar Upazila Health Complex, Jessore, Bangladesh
  • Dr. Homyera Koly Medical Officer, Department of Obstetrics and Gynaecology, Sher-E-Bangla Medical College Hospital, Barisal, Bangladesh.
  • Dr. Kamrun Nahar FCPS Subspeciality Student (Fetomaternal Medicine), Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
  • Dr. Dilshad Rifaha Medical Officer, Khilgoan Urban Dispensary, Dhaka, Bangladesh.
Keywords: Gestational diabetes mellitus (GDM), Metabolic, Neonatal, Serum vitamin B12

Abstract

Background: Gestational diabetes mellitus is one of the most common metabolic disorders during pregnancy and associated with increased maternal and neonatal morbidities. Low serum vitamin B 12 level have been associated with the risk of developing gestational diabetes mellitus (GDM). Objectives: The aim of this study was to find out any association of serum vitamin B12 with GDM. Methods: This cross-sectional comparative study was conducted in the department of Obstetrics and Gynaecology, BSMMU during October, 2017 to February, 2020. A total of 86 pregnant women between 18 to 40 years of age attended antenatal clinic and admitted in hospital in their 29 to 40 weeks of pregnancy were included in this study from 211 pregnant women. Among them 43 diagnosed cases of GDM were considered as group A and rest 43 without GDM were considered as group B. Statistical analyses of the results were be obtained by using window-based Microsoft Excel and Statistical Packages for Social Sciences (SPSS-24). Results: Serum vitamin B12 concentration was measured. The mean serum vitamin B12 level was 148.88±13.91 in group A and 182.70±27.16 in group B. The mean vitamin B12 level was statistically significantly low in GDM group than non GDM group (p=0.001). There was a significant negative correlation of serum vitamin B12 level with fasting plasma glucose (r=-0.561, p<0.001) and plasma glucose 2 hours after 75g glucose in GDM patient (r=-0.258, p=0.017). Therefore, low serum vitamin B12 can be regarded as a significant risk factor for the development of GDM. Conclusion: The association of Vitamin B12 with gestational diabetes mellitus (GDM) generally highlights that low Vitamin B12 levels may be associated with an increased risk of developing GDM. Vitamin B12 levels during pregnancy may play a role in reducing the risk of GDM. Regular monitoring and possible supplementation in deficient women could be beneficial as part of prenatal care.

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CITATION
DOI: 10.26838/MEDRECH.2024.11.6.740
Published: 2024-11-13
How to Cite
1.
Dr. Nusrat Jahan Khan, Dr. Begum Nasrin, Dr. Saila SharminTithi, Dr. Homyera Koly, Dr. Kamrun Nahar, Dr. Dilshad Rifaha. Association of Vitamin B12 with Gestational Diabetes Mellitus. Med. res. chronicles [Internet]. 2024Nov.13 [cited 2024Dec.4];11(6):247-55. Available from: https://medrech.com/index.php/medrech/article/view/729
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Original Research Article