Empagliflozin, Linagliptin, and Metformin in a triple fixed-dose combination for individuals with type 2 diabetes

  • Dr. C. B. Prasad General Physiscian, Hospital Road, Sitamadhi 843302, Darbhanga
  • Dr. Deepak Mahendru General Physician, Kalyani Hospital, Yamunanagar,135001
  • Dr. Ganesh Dahiwal Consultant Physician, Plot no 25 Nandigram Colony,Gajnan Maharaj Mandir, Essar Petroleum Pundlik, Nagar Road Garkheda, Aurangabad -431009
  • Dr. Jugal Bihari Gupta General Medicine. Plot No 53, Jawahar Colony, Tonk Road, Jaipur -302015
  • Dr. Jom Jacob Nellisserry Daibetologist, Bishop Alappatt Mission Hospital Kattoor, Thrissur 680702
Keywords: Empagliflozin, Linagliptin, Metformin

Abstract

As per the International Diabetes Federation (IDF), the percentage of patients with type 2 diabetes mellitus (T2DM) is increasing globally. Tight glycemic control is a crucial aspect of the management of T2DM due to the progressive nature of the disease. Evidence advises that aggressive glycemic control is beneficial not only for the short-term but also for the long-term well-being of patients. Due to the progressive nature of T2DM, first-line therapy often fails to provide effective glycemic control, necessitating the addition of add-on therapy. Hence, FDCs can play a crucial role in achieving glycemic targets effectively. Also, patients who are unable to tolerate metformin or who experience side effects of metformin monotherapy receive fixed-dose combinations (FDCs) of various other oral antidiabetic agents (OAD) including sodium-glucose co-transporter-2 (SGLT-2) inhibitors, dipeptidyl peptidase (DPP-4) inhibitors, thiazolidinediones (TZDs), sulfonylureas (SUs), glucagon-like peptide-1 (GLP-1) antagonist, and basal insulin. The addition of the third agent can also be considered to enhance treatment efficacy.

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CITATION
DOI: 10.26838/MEDRECH.2022.9.2.586
Published: 2022-04-13
How to Cite
1.
Prasad CB, Mahendru D, Dahiwal G, Gupta JB, Nellisserry JJ. Empagliflozin, Linagliptin, and Metformin in a triple fixed-dose combination for individuals with type 2 diabetes. Med. res. chronicles [Internet]. 2022Apr.13 [cited 2022May22];9(2):99-106. Available from: https://medrech.com/index.php/medrech/article/view/569
Section
Original Research Article