Empagliflozin, Linagliptin, and Metformin in a triple fixed-dose combination for individuals with type 2 diabetes
As per the International Diabetes Federation (IDF), the percentage of patients with type 2 diabetes mellitus (T2DM) is increasing globally. Tight glycemic control is a crucial aspect of the management of T2DM due to the progressive nature of the disease. Evidence advises that aggressive glycemic control is beneficial not only for the short-term but also for the long-term well-being of patients. Due to the progressive nature of T2DM, first-line therapy often fails to provide effective glycemic control, necessitating the addition of add-on therapy. Hence, FDCs can play a crucial role in achieving glycemic targets effectively. Also, patients who are unable to tolerate metformin or who experience side effects of metformin monotherapy receive fixed-dose combinations (FDCs) of various other oral antidiabetic agents (OAD) including sodium-glucose co-transporter-2 (SGLT-2) inhibitors, dipeptidyl peptidase (DPP-4) inhibitors, thiazolidinediones (TZDs), sulfonylureas (SUs), glucagon-like peptide-1 (GLP-1) antagonist, and basal insulin. The addition of the third agent can also be considered to enhance treatment efficacy.
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