Copper and copper containing pesticide as copper oxychloride toxicity and its adverse effects on animal and human health

  • Mahmoud M. Elalfy Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Egypt
  • Mohamed S. Abomosallam Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Egypt
  • Fathy Sleem Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Egypt
  • Mona Elhadidy Medical physiology department faculty of medicine, Mansoura university, Egypt, medical physiology, faculty of medicine, Al Baha University, KSA
Keywords: Copper, copper oxychloride, copper-containing pesticide

Abstract

Copper is a trace element and has a vital role in homeostasis but it has cumulative effects and may be hazardous to the animal, human, and environment. Copper is a vital trace element to all living as it participates in various metabolic processes and is controlled via complicated homeostatic mechanisms, but excess copper has a deleterious effect in organisms as it stimulates free radical production in the living cell, lipid peroxidation, and disturbs the whole-body antioxidant capacity. Although its beneficial effect, it has a hazardous effect on health as it has genotoxic, developmental toxicity, and hepatic toxicity in experimental animals

Downloads

Download data is not yet available.

References

Ghani S, Bakochristou F, ElBialy EMAA, Gamaledin SMA, Rashwan MM, Abdelhalim AM, et al. Design challenges of agricultural greenhouses in hot and arid environments–A review. Engineering in Agriculture, Environment and Food. 2019;12(1):48-70.

Adenle AA, Wedig K, Azadi H. Sustainable agriculture and food security in Africa: The role of innovative technologies and international organizations. Technology in Society. 2019;58:101143.

Bakre DS, Kaliwal BB. In-vitro Assessment of Carbendazim and Copper oxychloride cytotoxicity on HaCaT and HepG2 human cell lines. Journal of Applied Biology & Biotechnology Vol. 2017;5(03):023-9.

Fitton N, Alexander P, Arnell N, Bajzelj B, Calvin K, Doelman J, et al. The vulnerabilities of agricultural land and food production to future water scarcity. Global Environmental Change. 2019;58:101944.

Parron T, Hernandez A, Pla A, Villanueva E. Clinical and biochemical changes in greenhouse sprayers chronically exposed to pesticides. Human & experimental toxicology. 1996;15(12):957-63.

Zhang A, Luo W, Sun J, Xiao H, Liu W. Distribution and uptake pathways of organochlorine pesticides in greenhouse and conventional vegetables. Science of the Total Environment. 2015;505:1142-7.

Kreuger J, Graaf S, Patring J, Adielsson S. Pesticides in surface water in areas with open ground and greenhouse horticultural crops in Sweden 2008. 2010.

Bojacá CR, Arias LA, Ahumada DA, Casilimas HA, Schrevens E. Evaluation of pesticide residues in the open field and greenhouse tomatoes from Colombia. Food Control. 2013;30(2):400-3.

Jayaraj R, Megha P, Sreedev P. Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment. Interdisciplinary toxicology. 2016;9(3-4):90.

Gilden RC, Huffling K, Sattler B. Pesticides and health risks. Journal of Obstetric, Gynecologic & Neonatal Nursing. 2010;39(1):103-10.

Gerecke AC, Schärer M, Singer HP, Müller SR, Schwarzenbach RP, Sägesser M, et al. Sources of pesticides in surface waters in Switzerland: pesticide load through waste water treatment plants––current situation and reduction potential. Chemosphere. 2002;48(3):307-15.

Garcês A, Pires I, Rodrigues P. Teratological effects of pesticides invertebrates: A review. Journal of Environmental Science and Health, Part B. 2020;55(1):75-89.

STANIĆ S. Genotoxic effects of fungicide Copper oxychloride on Drosophila melanogaster. Periodicum biologorum. 2008;110(4):347-9.

Remor AP, Totti CC, Moreira DA, Dutra GP, Heuser VD, Boeira JM. Occupational exposure of farmworkers to pesticides: biochemical parameters and evaluation of genotoxicity. Environment international. 2009; 35(2): 273-8.

Husak V. Copper and copper-containing pesticides: metabolism, toxicity, and oxidative stress. Journal of Vasyl Stefanyk Precarpathian National University. 2015(2, no. 1):39-51.

Laurén DJ, McDonald D. Acclimation to copper by rainbow trout, Salmo gairdneri: physiology. Canadian Journal of Fisheries and Aquatic Sciences. 1987;44(1):99-104.

Helling B, Reinecke S, Reinecke A. Effects of the fungicide copper oxychloride on the growth and reproduction of Eisenia fetida (Oligochaeta). Ecotoxicology and environmental safety. 2000;46(1):108-16.

Kamunde CN, Grosell M, Lott JN, Wood CM. Copper metabolism and gut morphology in rainbow trout (Oncorhynchus mykiss) during chronic sublethal dietary copper exposure. Canadian Journal of Fisheries and Aquatic Sciences. 2001;58(2):293-305.

Shivanandappa T, Krishnakumari M, Majumder S. Testicular atrophy in Gallus domesticus fed acute doses of copper fungicides. Poultry science. 1983;62(2):405-8.

Antolı́n I, Mayo JC, Sainz RMa, del Brı́o MadlA, Herrera F, Martı́n V, et al. Protective effect of melatonin in a chronic experimental model of Parkinson’s disease. Brain research. 2002;943(2):163-73.

Osman AH, El-Shama SS, Osman As, ABD Elhameed AK. Toxicological and pathological evaluation of prolonged bromuconazole fungicide exposure in male rats. The Medical Journal of Cairo University. 2011;79(2).

Sevcikova M, Modra H, Blahova J, Dobsikova R, Plhalova L, Zitka O, et al. Biochemical, hematological and oxidative stress responses of common carp (Cyprinus carpio L.) after sub-chronic exposure to copper. Veterinarni Medicine. 2016;61(1).

Waheed S, Kamal A, Malik RN. Human health risk from the organ-specific accumulation of toxic metals and response of antioxidants in edible fish species from Chenab River, Pakistan. Environmental science and pollution research. 2014;21(6):4409-17.

Lushchak VI. Environmentally induced oxidative stress in aquatic animals. Aquatic toxicology. 2011;101(1):13-30.

Fuentealba I, Haywood S. Cellular mechanisms of toxicity and tolerance in the copper‐loaded rat. I. Ultrastructural changes in the liver. Liver. 1988;8(6):372-80.

Iwase J, Furukawa H, Hiramatsu T, Bouteau F, Mancuso S, Tanaka K, et al. Protection of tobacco cells from oxidative copper toxicity by catalytically active metal-binding DNA oligomers. Journal of experimental botany. 2014;65(5):1391-402.

El-Hak HNG, Mobarak YM. The ameliorative impacts of curcumin on copper oxychloride-induced hepatotoxicity in rats. The Journal of Basic and Applied Zoology. 2018;79(1):1-10.

Grădilă M. Environmental risk assessment of some copper-based fungicides according to the requirements of good laboratory practice. AgroLife Scientific Journal. 2015;4(1):74-8.

Nalbur BE, Eleren SÇ, Şahin S, Alkan U. Toxic Effects of Copper‐Based and Synthetic Organic Pesticides on Activated Sludge. CLEAN–Soil, Air, Water. 2012;40(1):39-44.

Chung MK, Baek SS, Lee SH, Kim H, Choi K, Kim JC. Combined repeated dose and reproductive/developmental toxicities of copper monochloride in rats. Environmental Toxicology: An International Journal. 2009;24(4):315-26.

Yologlu E, Ozmen M. Effects of methyl parathion and copper oxychloride application on earthworms (lumbricus terrestris) in an apricot orchard. Fresenius Environmental Bulletin. 2013;22(12):3442-7.

Gunay N, Yildirim C, Karcioglu O, Gunay NE, Yilmaz M, Usalan C, et al. A series of patients in the emergency department diagnosed with copper poisoning: recognition equals treatment. The Tohoku journal of experimental medicine. 2006;209(3):243-8.

Hloch O, Charvát J. Acute copper poisoning by suicidal attempt. Vnitrni lekarstvi. 2012;58(4):325-8.

Mercer JF. The molecular basis of copper-transport diseases. Trends in molecular medicine. 2001;7(2):64-9.

Bayram S, Genc A, Buyukleyla M, Rencuzogullari E. Genotoxicity and cytotoxicity of copper oxychloride in cultured human lymphocytes using cytogenetic and molecular tests. Cytotechnology. 2016;68(5):2027-36.

Pirtskhelani A, Pirtskhelani N, Gakhokidze R, Bichikashvili N, Kalandiia E. The influence of poly vitamin complex polijen on mutagenic and cytotoxic effect of copper oxychloride in white mice. Georgian medical news. 2008(159):44-7.

Brewer, G. J. Copper excess, zinc deficiency, and cognition loss in Alzheimer's disease. Biofactors, 2012 38(2), 107-113.

Preeti, S., Nidhi, S., & Joshi, S. C. Effects of copper oxychloride on reproductive function of male albino rats. National Journal of Life Sciences, 2009, 6(2), 157-161.

Hutanu, D. The effect of copper chloride upon the follicles stage in mouse ovaries. Annals of the Romanian Society for Cell Biology,2012, 17(1).

Yasmin, S., & D'Souza, D. Effects of pesticides on the growth and reproduction of earthworm: a review. Applied and Environmental Soil Science, 2010. 42 (4), 101-110.

Jezierska, B., Ługowska, K., & Witeska, M. The effects of heavy metals on embryonic development of fish (a review). Fish physiology and biochemistry, 2009, 35(4), 625-640.

Checiu, I., Checiu, M., Checiu, D., Capalnasan, I., & Tuduce, I. (2003). Investigations of teratogenic effects induced by copper upon early postimplantation mouse embryos. Annals of West University of Timişoara, ser. Biology, 2003 (506) 87-94.

Checiu, I., Checiu, M., Tuduce, I., Ilut, I., & Hutanu, D. Teratogenic effects of copper upon early postimplantational mouse embryos–in vitro experimental investigation. Annals of West University of Timişoara, ser. Biology, 2008 (11) 51-56.

Checiu, I., Maria, C., Ioana, T., & Checiu, D. Teratogenic effects of copper upon mice preimplantational embryos (in vitro and in vivo) experimental investigations. Annals of West University of Timisoara, Series of Biology,2001 (4) 58-69.

Checiu, M., Checiu, I., Ilut, I., Tuduce, I., & Hutanu, D. C. The effect of acute maternal CuCl2 intoxication upon mouse fetal skeleton. mental, 2004; 81(10), 8-10.

Ferm, V. H., & Hanlon, D. P. Toxicity of copper salts in hamster embryonic development. Biology of reproduction, 1974;11(1), 97-101.

Chang, C. C., & Tatum, H. J. Absence of teratogenicity of intrauterine copper wire in rats, hamsters and rabbits. Contraception, 1973;7(5), 413-434.

Dicarlo Jr, F. J. Syndromes of cardiovascular malformations induced by copper citrate in hamsters. Teratology, 1980; 21(1), 89-101.

Reinstein, N. H., Lönnerdal, B., Keen, C. L., & Hurley, L. S. Zinc-copper interactions in the pregnant rat: fetal outcome and maternal and fetal zinc, copper and iron. The Journal of nutrition, 1984;114(7), 1266-1279.

Uriu-Adams, J. Y., & Keen, C. L. Copper, oxidative stress, and human health. Molecular aspects of medicine, 2005; 26(4-5), 268-298.

Mahrosh, U., Kleiven, M., Meland, S., Rosseland, B. O., Salbu, B., & Teien, H. C. Toxicity of road deicing salt (NaCl) and copper (Cu) to fertilization and early developmental stages of Atlantic salmon (Salmo salar). Journal of hazardous materials, 2004(280) 331-339.

Pagano, G., Iaccarino, M., De Biase, A., Meri, S., Warnau, M., Oral, R., & Trieff, N. M. Factors affecting R6 fungicide toxicity on sea urchin fertilization and early development: roles of exposure routes and mixture components. Human & experimental toxicology,2001; 20(8), 404-411.

Mohamed Abomosallam, Mahmoud Elalfy, Fathy Sleem. Postnatal toxicity of copper oxychloride in lactating female albino rats. Mansoura Veterinary Medical Journal 2020; 21, 3: 91-98.

Elalfy MM, et al. Maternal Toxicity and Ultrastructural Changes of Copper Oxy-Chloride in Pregnant Female Albino Rats. Int J Zoo Animal Biol 2019, 2(3): 000159.

Elalfy MM, et al. The Cytotoxic Combined Effects of Mixtures of Copper Oxychloride and Chlorfenapyr in HepG2 Cells and Postnatal Model of Toxicity in Female Sprague Dawley rats and its Pups. Int J Zoo Animal Biol 2020, 3(3): 00022.

CITATION
DOI: 10.26838/MEDRECH.2021.8.2.486
Published: 2021-04-26
How to Cite
1.
Elalfy MM, Abomosallam MS, Sleem F, Elhadidy M. Copper and copper containing pesticide as copper oxychloride toxicity and its adverse effects on animal and human health. Med. res. chronicles [Internet]. 2021Apr.26 [cited 2024Dec.4];8(2):89-8. Available from: https://medrech.com/index.php/medrech/article/view/483
Section
Review Article