FREQUENCY OF H.PYLORI SEROPOSITIVITY IN PATIENTS WITH HEPATIC ENCEPHALOPATHY
Abstract
Objective: To determine the frequency of Helicobacter Pylori seropositivity in patients with hepatic encephalopathy. Study Design: Descriptive cross-sectional study. Place & Duration of the Study: This study was conducted at the Department of Medicine of Khyber Teaching Hospital Peshawar from February 2014 till September 2014.
Methodology: This study included 137 cirrhotic patients and data was collected on a structured questionnaire. Informed written consent was taken from patients or their attendants, who fulfilled the inclusion criteria. Both male and female patients (age 15 and above) were assessed in the OPD and admitted to the Medical Unit for workup. All patients were investigated for H. Pylori Serology by sending 5ml of venous blood to the same laboratory. Data was analyzed using SPSS version16.
Results: The mean age of all the 137 patients was 41.36years ± 10.48SD. Out of total patients of 137, 75 (54.75%) were males and 62(45.55%) were females. H. pylori serology was positive in 94 (68.61%) of the patients while 43 (31.39%) had negative antibody results for H. pylori. West-Haven classification of the grades of Hepatic Encephalopathy showed that 25 (18.25%) patients had grade 1, 33 patients (24.09%) had grade 2, 40 patients (29.2%) had grade 3 and 39 participants (28.47%) were in grade 4 Encephalopathy respectively.
Conclusion: Cirrhotic patients are more commonly infected with H. Pylori and the vast majority of them (68.61%) have positive antibodies against the causative pathogen.
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References
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