PREOPERATIVE THYROID FINE NEEDLE ASPIRATION BIOPSY FINDINGS IN PATIENTS UNDERGOING TOTAL THYROIDECTOMY FOR NODULAR GOITER
Abstract
Objective: Our purpose was to retrospectively investigate the postoperative histopathological results of the 53 patients who underwent total thyroidectomy operation at our hospital and compare them to their preoperative ultrasound-guided fine-needle aspiration biopsy (TFNAB) results.
Methods: Surgical records of the patients were reviewed together with preoperative thyroid fine-needle aspiration cytology (TFNAC) results. Results: The mean age (±SD) of 53 patients (12 males, 41 females) was 50±12.3 years (min: 19, max: 77). Mean age was 56.3±12.8 years (min: 34, max: 77) for males and 48.1±11.6 years (min: 19, max: 69) for females (p=0.14). Preoperative TFNAC results of 53 patients were: 11, Bethesda-1; 9, Bethesda-2; 14, Bethesda-3; 13, Bethesda-4, and 6 were Bethesda-5, respectively. Postoperative pathology results of 53 patients were of 23, nodular goiter; of 24, thyroid papillary carcinoma; of 3, chronic lymphocytic thyroiditis; 2, follicular adenoma;1, amyloidosis, respectively. The patients who were diagnosed as papillary thyroid carcinoma were determined malign; the others were determined as benign. So the ratio of malignancy of the patients who were operated was 45%. The rate of malignancy was 30% for patients with TFNAC results indicating Bethesda-1 and Bethesda-2 which did not strongly suggest malignancy but who underwent total thyroidectomy on the basis of other clinical manifestations; for patients operated due to a higher probability of malignancy as suggested by TFNAC results indicating Bethesda-3 and above categories, the malignancy rate was 55%.
Conclusion: TFNAC results should be taken into account in addition to clinical and ultrasonographic features when considering surgery for such patients.
Downloads
References
2- Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 7, 1977, 481-93.
3- Brander A, Viikinkoski P, Nickels J, Kivisaari L. Thyroid gland: US screening in a random adult population. Radiology. 181, 1991, 683-7.
4- Ezzat S, Sarti DA, Cain DR, Braunstein GD. Thyroid incidentalomas. Prevalence by palpation and ultrasonography. Arch Intern Med. 154, 1994, 1838-40.
5- Mortensen JD, Bennett WA, Woolner LB. Incidence of carcinoma in thyroid glands removed at 1000 consecutive routine necropsies. Surg Forum. 5, 1955, 659-63.
6- Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al, American Thyroid Association (ATA) Guidelines Task-force on Thyroid Nodules and Differentiated Thyroid Cancer. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 19, 2009, 1167-214.
7- Reading CC, Charboneau JW, Hay ID, Sebo TJ. Sonography of thyroid nodules: a "classic pattern" diagnostic approach. Ultrasound Q. 21(3), 2005, 157-65.
8- Kim EK, Chung WY, Oh KK, Kim DI, Lee JT, Yoo HS. New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. Am J Roentgenol. 17, 2002, 687–91.
9- Hoang JK, Lee WK, Lee M, Johnson D, Farrell S. US Features of thyroid malignancy: pearls and pitfalls. Radiographics. 27, 2007, 847–60.
10- Rago T, Vitti P. Potential value of elastosonography in the diagnosis of malignancy in thyroid nodules. Q J Nucl Med Mol Imaging. 53(5), 2009, 455-64.
11- Moon HG, Jung EJ, Park ST, Ha WS, Choi SK, Hong SC, et al. Role of ultrasonography in predicting malignancy in patients with thyroid nodules. World J Surg. 31, 2007, 1410–6.
12- Lin JD, Chao TC, Huang BY, Chen ST, Chang HY, Hsueh C. Thyroid cancer in the thyroid nodules evaluated by ultrasonography and fine-needle aspiration cytology. Thyroid. 15, 2005, 708 -17.
13- Perros P. British Thyroid Association, Royal College of Physicians. Guidelines for the management of thyroid cancer. 2nd ed. London: Royal College of Physicians; 2007.
14- Morris LF, Ragavendra N, Yeh MW. Evidence-based assessment of the role of ultrasonography in the management of benign thyroid nodules. World J Surg. 32, 2008, 1253–63.
15- Griffin JE. Management of thyroid nodules. Am J Med Sci. 296(5), 1988, 336-47.
16- Hawkins F, Bellido D, Bernal C, Rigopoulou D, Ruiz Valdepeñas MP, Lazaro E, et al. Fine-needle aspiration biopsy in the diagnosis of thyroid cancer and thyroid disease. Cancer. 59(6), 1987, 1206-9.
17- Cibas ES, Ali SZ. NCI Thyroid FNA State of the Science Conference. The Bethesda System For Reporting Thyroid Cytopathology. Am J Clin Pathol. 132(5), 2009, 658-65.
18- Wienke JR, Chong WK, Fielding JR, Zou KH, Mittelstaedt CA. Sonographic features of benign thyroid nodules. Interobserver reliability and overlap with malignancy American Institute of Ultrasound in Medicine. J Ultrasound Med. 22, 2003, 1027–31.
19- Stojadinovic A, Peoples GE, Libutti SK, Henry LR, Eberhardt J, Howard RS. Development of a clinical decision model for thyroid nodules. BMC Surg. 9, 2009, 12.
20- Baloch ZW, LiVolsi VA, Asa SL, Rosai J, Merino MJ, Randolph G, et al. Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: A synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol. 36, 2008, 425–37.
21- Gharib H, Goellner JR. Fine needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med 118, 1993, 282-9.
22- Krane JF, Vanderlaan PA, Faquin WC, Renshaw AA. The atypia of undetermined significance/follicular lesion of undetermined significance: Malignant ratio: A proposed performance measure for reporting in The Bethesda System for thyroid cytopathology. Cancer Cytopathol. 120, 2012, 111–6.
23- Aschebrook-Kilfoy B, Ward MH, Sabra MM, Devesa SS. Thyroid cancer incidence patterns in the United States by histologic type, 1992- 2006. Thyroid. 21(2), 2011, 125-34.
24- AACE/AME Task Force on Thyroid Nodules. American Association of Clinical Endocrinologists and Associazione Medici Endocrinology medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract. 16(Suppl. 1), 2010, 1-43.
25- Milas Z, Shin J, Milas M. New guidelines for the management of thyroid nodules and differentiated thyroid cancer. Minerva Endocrinol. 36(1), 2011, 53-70.