KETOCONAZOLE EFFECT FOR THE PREVENTION OF THE ARDS IN HOSPITALIZED PATIENTS IN ICU

  • Sherwin Shokoohi Department of Infectious Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Latif Gachkar Department of Infectious Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Seyed Alireza Mousavi Infectious Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Seyed Hossein Shahcheraghi Infectious Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Dr. Vibhor Jain School of Pharmacy, Chouksey Engineering College, Bilaspur, India
Keywords: ARDS, Ketoconazole, ICU

Abstract

Objective: The acute respiratory distress syndrome (ARDS) is a common complication of a variety of illnesses and is associated with significant morbidity and mortality. It develops following a number of predisposing conditions. Ketoconazole can modulate inflammatory pathways known to be involved in ARDS. The aim of this study was to investigate, Ketoconazole effect for the prevention of the ARDS.

Material and Methods: In the Loghman Hakim’s Hospital of Tehran, Iran (study hospital), we investigated the ketoconazole effect in the prevention of the ARDS as a clinical trial. Patients were placed into two groups receiving oral ketoconazole and placebo. Finally, statistical analysis was performed using SPSS (Version 11.5).

Results: There was no significant difference between two groups (receiving ketoconazole and placebo) in terms of sexual distribution. Also, there were no significant differences between them in terms of age groups mean and duration mean of ICU stay.

Conclusion: Data related to the present study do not support the use of ketoconazole for the prevention of ARDS in Iran.

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How to Cite
1.
Shokoohi S, Gachkar L, Mousavi SA, Shahcheraghi SH, Jain V. KETOCONAZOLE EFFECT FOR THE PREVENTION OF THE ARDS IN HOSPITALIZED PATIENTS IN ICU. Med. res. chronicles [Internet]. 2015Oct.15 [cited 2024Dec.22];2(5):644-8. Available from: https://medrech.com/index.php/medrech/article/view/132
Issue
Vol. 2 No. 5 (2015): Sep-Oct
Section
Original Research Article

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