KETOCONAZOLE EFFECT FOR THE PREVENTION OF THE ARDS IN HOSPITALIZED PATIENTS IN ICU

  • Sherwin Shokoohi Department of Infectious Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Latif Gachkar Department of Infectious Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Seyed Alireza Mousavi Infectious Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Seyed Hossein Shahcheraghi Infectious Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Dr. Vibhor Jain School of Pharmacy, Chouksey Engineering College, Bilaspur, India
Keywords: ARDS, Ketoconazole, ICU

Abstract

Objective: The acute respiratory distress syndrome (ARDS) is a common complication of a variety of illnesses and is associated with significant morbidity and mortality. It develops following a number of predisposing conditions. Ketoconazole can modulate inflammatory pathways known to be involved in ARDS. The aim of this study was to investigate, Ketoconazole effect for the prevention of the ARDS.

Material and Methods: In the Loghman Hakim’s Hospital of Tehran, Iran (study hospital), we investigated the ketoconazole effect in the prevention of the ARDS as a clinical trial. Patients were placed into two groups receiving oral ketoconazole and placebo. Finally, statistical analysis was performed using SPSS (Version 11.5).

Results: There was no significant difference between two groups (receiving ketoconazole and placebo) in terms of sexual distribution. Also, there were no significant differences between them in terms of age groups mean and duration mean of ICU stay.

Conclusion: Data related to the present study do not support the use of ketoconazole for the prevention of ARDS in Iran.

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References

1. Serpa Neto A, Simonis FD, Schultz MJ. How to ventilate patients without acute respiratory distress syndrome? Curr Opin Crit Care 2015; 21 (1):65-73.
2. Beitler JR, Schoenfeld DA, Thompson BT. Preventing ARDS: progress, promise, and pitfalls. Chest 2014; 146 (4):1102-13.
3. Marraro GA, Chen C, Piga MA, et al. Acute respiratory distress syndrome in the pediatric age: an update on advanced treatment. Zhongguo Dang Dai Er Ke Za Zhi 2014; 16 (5):437-47.
4. Han S, Mallampalli RK. The Acute Respiratory Distress Syndrome: From Mechanism to Translation. J Immunol 2015; 194 (3):855-860.
5. Mehta S, Cook DJ, Skrobik Y, et al. A ventilator strategy combining low tidal volume ventilation, recruitment maneuvers, and high positive end-expiratory pressure does not increase sedative, opioid, or neuromuscular blocker use in adults with acute respiratory distress syndrome and may improve patient comfort. Ann Intensive Care 2014; 4:33.
6. Tagami T, Nakamura T, Kushimoto S, et al. Early-phase changes of extravascular lung water index as a prognostic indicator in acute respiratory distress syndrome patients.Ann Intensive Care 2014;4:27.
7. Balke L, Both M, Arlt A, et al. Severe adult respiratory distress syndrome from goodpasture syndrome. Survival using extracorporeal membrane oxygenation. Am J Respir Crit Care Med 2015; 191(2):228-9.
8. Gong MN, Ferguson ND. Lung-protective ventilation in acute respiratory distress syndrome. How soon is now? Am J Respir Crit Care Med 2015; 191 (2):125-6.
9. Li XY, Sun B, Wang CT, et al. A Follow-up Study on Acute Respiratory Distress Syndrome Survivors after Extracorporeal Membrane Oxygenation by Pulmonary High Resolution CT. Arch Iran Med 2015; 18 (1):6-11.
10. Schell-Chaple HM, Puntillo KA, Matthay MA, et al. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care 2015; 24 (1):15-23.
11. Mun YS, Lee MS, Park JS, et al. An unusual case of candidemia presenting as acute respiratory distress syndrome after a small bowel bezoar removal operation. Ann Surg Treat Res 2015; 88 (1):48-51.
12. Brummel N, Chandrasekhar R, Ely EW. Willie sutton and the future of acute respiratory distress syndrome research. Am J Respir Crit Care Med 2015; 191 (1):10-1.
13. Grasso C, Sciacca P, Giacchi V, et al. Effects of Sustained Lung Inflation, a lung recruitment maneuver in primary acute respiratory distress syndrome, in respiratory and cerebral outcomes in preterm infants. Early Hum Dev 2014; 91 (1):71-75.
14. Londhe C, Ganeriwal A, DeSouza R. Study of clinical profile of acute respiratory distress syndrome and acute lung injury in Plasmodium vivax malaria. J Vector Borne Dis 2014; 51 (4):339-42.
15. Fujishima S. Pathophysiology and biomarkers of acute respiratory distress syndrome. J Intensive Care 2014; 2 (1):32.
16. Morisawa K, Fujitani S, Taira Y, et al. Difference in pulmonary permeability between indirect and direct acute respiratory distress syndrome assessed by the transpulmonary thermodilution technique: a prospective, observational, multi-institutional study. J Intensive Care 2014; 2 (1):24.
17. Koh Y. Update in acute respiratory distress syndrome. J Intensive Care 2014; 2 (1):2.
18. Liew F, Martin D. Acute respiratory distress syndrome in the intensive care unit. Br J Hosp Med (Lond) 2014; 75 (12):672-7.
19. Sinuff T, Cook DJ, Peterson JC, et al. Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis. J Crit Care 1999; 14 (1):1-6.
20. Hurley AC, Volicer L, Blasi ZV. Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2000;283 (15):1995-2000.
How to Cite
1.
Shokoohi S, Gachkar L, Mousavi SA, Shahcheraghi SH, Jain V. KETOCONAZOLE EFFECT FOR THE PREVENTION OF THE ARDS IN HOSPITALIZED PATIENTS IN ICU. Med. res. chronicles [Internet]. 2015Oct.15 [cited 2024Nov.22];2(5):644-8. Available from: https://medrech.com/index.php/medrech/article/view/132
Issue
Vol. 2 No. 5 (2015): Sep-Oct
Section
Original Research Article

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