AN INVESTIGATION AND MANAGEMENT OF OUTBREAK OF HAND FOOT AND MOUTH DISEASE IN SOUTHERN INDIA

  • Manish Kumar Assistant Professor, Department of Pediatrics, Military Hospital, Jaipur, India
  • Rigvardhan Associate Professor, Department of Pathology, Command Hospital (Central Command), Lucknow India
  • Mukul Bajpai Assistant Professor, Department of Microbiology, Command Hospital (Central Command), Lucknow India
Keywords: Hand foot and mouth disease (HFMD), Coxsackie virus A16, Enterovirus 71

Abstract

Introduction: Hand foot and mouth disease (HFMD) is a viral illness that mainly affects young children is mostly caused by Coxsackie A16 or Enterovirus 71. In India, HFMD outbreaks are uncommon. The authors report an outbreak of HFMD in Wellington, Dist Conoor (Tamilnadu) India recently.

Methods: Based on clinical parameters a case definition was adopted. Cases were recorded on structured case investigation forms. Laboratory diagnosis was done by using Enterovirus PCR in 5’non coding region and nucleotide sequencing of VP1.

Results: 101 children with the clinical diagnosis of HFMD reported to the hospital within 17 days. The age ranged from 10 months to 11 yrs and 5 months. HFMD started with fever and common cold/ nasal discharge. Mouth sores were present in 69 (68.3%) children, multiple vesiculopapular rash with erythematous base were observed over hands and feet in 88 (87.1%) and 83 (82.17%) cases respectively. Of the 34 various types of samples collected, 18 were found to be positive for Coxsackie A16.

Conclusion: An epidemic of HFMD swept through Dist Conoor due to Coxsackie A16 which was controlled by adopting simple yet effective measures. Early  diagnosis and awareness about this highly contagious disease can help prevent and contain an epidemic.

Downloads

Download data is not yet available.

References

1. The Times of India: New mild virus targets kid under 5 years of age. 18 Sep 2009.
2. Lee TC, Guo HR, Su HJ, Yang YC, Chang HL, Chen KT. Diseases caused by enterovirus 71 infection. Pediatr Infect Dis J. 2009 Oct;28(10):904-10
3. Ang LW, Koh BK, Chan KP, Chua LT, James L, Goh KT. Epidemiology and control of hand, foot and mouth disease in Singapore, 2001-2007.Ann Acad Med Singapore. 2009 Feb;38(2):106-12.
4. Ho M, Chen E-R, Hsu K-H, Twu S-J, Chen K-T, Tsai S-F, Wang J-R, Shih SR: An epidemic of enterovirus 71 infection in Taiwan. New England Journal of Medicine 1999, 341(13):929-935.
5. Chan K, Goh K, Chong C, Teo E, Lau G, Ling A: Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore. Emerg Infect Dis 2003, 9:78-85.
6. Ooi MH, Wong SC, Podin Y, Akin W, del Sel S, Mohan A, Chieng CH, Perera D, Clear D, Wong D, et al.: Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study. Clin Infect Dis 2007, 44(5):646-656.
7. Chang LY, Lin TY, Huang YC, Tsao KC, Shih SR, Kuo ML, Ning HC, Chung PW, Kang CM: Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998. The Pediatric Infectious Disease Journal 1999, 18(12):1092-1096.
8. Lindenbaum JE, Van Dyck PC, Allen RG: Hand, foot and mouth disease associated with coxsackie virus group B. Scand J Infect Dis 1975, 7:161-163
9. Goh KT, S Doraisngham, JL Tan GN Lim, SE Chev: An outbreak of Hand Foot and Mouth disease in Singapore. Bulletin of the WHO 60(6):965-969,1982.
10. Richardson HB, A Leibovitz: Hand Foot and Mouth disease in children. J Pediatrics 67(1):6-12, 1965.
11. Mark.JF, Syne MR. Outbreak of Coxsackievirus A16 Hand, Foot, and Mouth Disease in a Child Day-Care Center. American Journal of Public Health. December 1991,Vol.81,No.12
12. Robinson CR, Donae FW, Rhodes AJ. Report of an outbreak of febrile illness with pharyngeal lesions and exanthem : Toronto, summer 1957- isolation of
Coxsackie virus. Can Med Assoc J 1958;79;615-21.
13. Sasidharan CK,Sugathan P, Agrawal R, Khare S, Lal S, Jayaram Paniker CK. Hand-foot and mouth disease in calicut. Indian J Pediatr 2005;72:17-21.
14. Sharma N, Sarkar A, Mukherjee A. Ghosh A, Dhar S, Malakar R. Epidemic of Hand foot and mouth disease in West Bangal India in aug, 2007: a multicentric
study. Indian J Dermatol 2009:54(1):26-30.
15. Sandeep A, Gulhima A, Vanmalini T. Hand Foot and Mouth disease: emerging epidemic. Indian J Dermatol Venereol Leprol 2008; 74(5): 504- 505.
16. Saoji VA. Hand foot and mouth disease in Nagpur. Indian J Dermatol Venereol Leprol 2008; 74(5): 133-5.
17. Ooi MH, Wong SC, Podin Y, Akin W, del Sel S, Mohan A, Chieng CH, Perera D, Clear D, Wong D, et al.: Identification and validation of clinical predictors for the risk of neurological involvement in the children with hand foot and mouth disease in Sarawak
18. Li L, He Y, Yang H, Zhu J, Xu X, Dong J, et al. Genetic characteristics of Human Enterovirus 71 and Coxsackievirus A16 Circulating from 1999 to 2004 in Shenzhen, People’s Republic of china. J Clin Microbiol 2005;43:3835-9.
19. Chang, L. Y., T. Y. Lin, Y. C. Huang, K. C. Tsao, S. R. Shih, M. L. Kuo, H. C. Ning, P. W. Chung, and C. M. Kang. 1999. Comparison of enterovirus 71 and coxsackievirus A16 clinical illness during the Taiwan enterovirus epidemic, 1998. Pediatric. Infect. Dis. J. 18:1092-1096.
20. Chan LG, Parashar UD, Lye MS, Ong FG, Zaki SR, Alexander JP, Ho KK, Han LL, Pallansch MA, Suleiman AB, Jegathesan M, Anderson LJ: Deaths of children during an outbreak of hand, foot, and mouth disease in Sarawak, Malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group. Clin Infect Dis 2000, 31:678-683.
How to Cite
1.
Manish Kumar, Rigvardhan, Mukul Bajpai. AN INVESTIGATION AND MANAGEMENT OF OUTBREAK OF HAND FOOT AND MOUTH DISEASE IN SOUTHERN INDIA. Med. res. chronicles [Internet]. 1 [cited 2024Nov.6];3(1):115-23. Available from: https://medrech.com/index.php/medrech/article/view/152
Section
Original Research Article