Binswanger’s Disease

Abstract

On autopsy of brain, in some cases ischemic periventricular leukoencephalopathy is found not only this, CT SCAN and MRI has also shown deep white matter lesions in the aged persons usually present between 54 to 66 years of age ,this conditions is called as Binswanger’s disease is a progressive neurological disorder and is also called as sub cortical vascular dementia .There is no cure for this disease, which was resulted from thickening or narrowing of arteries (atherosclerosis) that supply blood to white matter of brain and that leads to the death of brain, brain tissues particularly basal ganglia and thalamus which are the deep structures of brain .it may be caused by rare hereditary disease called CADASIL. Symptoms usually seen in the patient's are, mood changes, loss of the ability to focus on tasks, a deterioration in thought processes (e.g., loss of memory and cognition), and mood changes. It does posses some risk factors such as hypertension and amyloid angiopathy, impaired auto regulation of cerebral blood flow in the elderly, and periventricular hypo-perfusion due to cardiac failure, arrhythmias, and hypotension. But for this disease, there is no specific treatment. Treatment is symptomatic; the most characteristic feature of Binswanger’s disease is psychomotor slowness. Persons with this disease often die within five years of the onset of the disease. It can coexist with Alzheimer’s disease and some other diseases. Scientists at the National Institute of Neurological Disorders and Stroke are reevaluating the definitions for many forms of dementia, including Binswanger disease.