KETOGENIC DIET AND ITS ROLE IN ELIMINATING MEDICINAL TREATMENT IN VARIOUS DISEASES
Keywords:
Ketogenic diet, cancer, diabetes, neurological diseases, obesity, cardiovascular diseases
Abstract
Very-low-carbohydrate diets or ketogenic diets have been used 1920s to treat Epilepsy. Ultimately it finished medication. They have become widely known as one of the most common methods for obesity treatment. Now work over the last few years their therapeutic potential in many conditions, such as diabetes, polycystic ovary syndrome, acne, neurological diseases, cancer and the amelioration of respiratory and cardiovascular disease risk factors have been of help. The possibility that modifying food intake can be useful for reducing or eliminating medicinal treatment, which are often lifelong with significant side effects. It calls for serious investigation. Meaning of physiological ketosis in the light of this evidence is considered possible mechanisms for the therapeutic actions of the ketogenic diet on different diseases. There are still some well understood ideas about ketogenic diets, which may remove superfluous thinking. It could prove to be a boon later.
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References
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2. WHO. Medicines: Corruption and Pharmaceuticals. WHO Fact Sheet, WHO, 2009.
3. Veech RL. The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids 2004; 70: 309–319.
4. Owen OE, Morgan AP, Kemp HG, Sullivan JM, Herrera MG, Cahill GF Jr. Brain metabolism during fasting. J Clin Invest 1967; 46: 1589–1595.
5. Kessler SK, Neal EG, Camfield CS, Kossoff EH. Dietary therapies for epilepsy: future research. Epilepsy Behav 2011; 22: 17–22.
6. Fukao T, Lopaschuk GD, Mitchell GA. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Prostaglandins Leukot Ess ent Fatty Acids 2004; 70: 243–251.
7. Veldhorst MA, Westerterp-Plantenga MS, Westerterp KR. Gluconeogenesis and energy expenditure after a highprotein, carbohydrate-free diet. Am J Clin Nutr 2009; 90: 519–526.
8. Krebs HA. The regulation of the release of ketone bodies by the liver. Adv Enzyme Regul 1966; 4: 339–354.
9. Paoli A, Canato M, Toniolo L, Bargossi AM, Neri M, Mediati M et al. The ketogenic diet: an underappreciated therapeutic option? Clin Ter 2011; 162:e145–e153.
10. Cahill GFJr. Fuel metabolism in starvation. Annu Rev Nutr 2006; 26: 1– 22.
11. Paoli A, Grimaldi K, Toniolo L, Canato M, Bianco A, Fratter A. Nutrition and acne: therapeutic potential of ketogenic diets. Skin Pharmacol Physiol2012; 25:
111–117.
12. Westerterp-Plantenga MS, Nieuwenhuizen A, Tome D, Soenen S, Westerterp KR. Dietary protein, weight loss, and weight maintenance. Annu Rev Nutr 2009; 29: 21–41.
13. Feinman RD, Fine EJ. Nonequilibrium thermodynamics and energy efficiency in weight loss diets. Theor Biol Med Model 2007; 4: 27.
14. Freedman MR, King J, Kennedy E. Popular diets: A scientific review. Obes Res 2001; 9 (Suppl 1), 1S–40S.
15. Brehm BJ, Seeley RJ, Daniels SR, D'Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab 2003; 88: 1617–1623.
16. Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR et al. Comparison of the atkins, zone, ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: The A TO Z weight loss study: a randomized trial. JAMA 2007; 297: 969–977.
17. Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I et al. Weight loss with a low-carbohydrate, mediterranean, or low-fat diet. N Engl J Med 2008; 359: 229–241. Fine EJ, Feinman RD. Thermodynamics of weight loss diets. Nutr Metab (Lond) 2004; 1: 15.
18. Halton TL, Hu FB. The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review. J Am Coll Nutr 2004; 23: 373–385.
19. Paoli A, Grimaldi K, Bianco A, Lodi A, Cenci L, Parmagnani A. Medium term effects of a ketogenic diet and a mediterranean diet on resting energy expenditure and respiratory ratio. BMC Proceedings 2012; 6, (Suppl 3): P37.
20. Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos Aet al. Ketosis and appetite-mediating nutrients and hormones after weight loss. Eur J
Clin Nutr 2013;, e-pub ahead of print 1 May 2013; doi:10.1038/ejcn.2013.90.
21. Veldhorst M, Smeets A, Soenen S, Hochstenbach-Waelen A, Hursel R, Diepvens K et al. Protein-induced satiety: effects and mechanisms of different proteins. Physiol Behav 2008; 94: 300–307.
22. Johnstone AM, Horgan GW, Murison SD, Bremner DM, Lobley GE. Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men
feeding ad libitum. Am J Clin Nutr 2008; 87: 44–55?
23. Paoli A, Cenci L, Fancelli M, Parmagnani A, Fratter A, Cucchi A et al. Ketogenic diet and phytoextracts comparison of the efficacy of mediterranean, zone and tisanoreica diet on some health risk factors. Agro Food Ind Hi-Tech 2010; 21: 24.
24. Nordmann AJ, Nordmann A, Briel M, Keller U, Yancy WSJr, Brehm BJ et al. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med 2006; 166: 285–293.
How to Cite
1.
Dr. Anil Batta. KETOGENIC DIET AND ITS ROLE IN ELIMINATING MEDICINAL TREATMENT IN VARIOUS DISEASES. Med. res. chronicles [Internet]. 2016Aug.31 [cited 2024Apr.25];3(04):409-22. Available from: https://medrech.com/index.php/medrech/article/view/192
Section
Original Research Article
