OVARIAN SERTOLI LEYDIG CELL TUMOUR: A RARE CASE OF SEX CORD STROMAL TUMOUR
Keywords:
Sertoli, SLCT, amenorrhea
Abstract
Sertoli Leydig cell tumor (SLCT) of ovary is an unusual neoplasm that belongs to a group of Sex Cord-Stromal tumors of Ovary and account for less than 0.5%of all primary ovarian neoplasms. Very few cases have been documented in the literature so far. Herein we report a case of Primary Sertoli-Leydig cell Tumor (SLCT) in a 16-years old girl who presented with amenorrhea of 7 months along with hirsutism and hoarseness of voice.
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References
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2. Dietrich JE, Kaplan A, Lopez H, Jaffee I. A case of poorly differentiated SertoliLeydig tumour of the ovary. J PediatrAdolesc Gynecol. 2004;17:49-52.
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clinical follow-up of Sertoli–Leydig cell tumours". Clinical Chemistry and Laboratory Medicine45 (5): 657–61.
6. Colombo Ni, Parma Ga. Ovarian sex cord-stromal tumors. In: Gershenson DM, Mcguire Mc, Gore M, Quinn MA, Thomas G, editors. Gynecologic Cancer. Elsevier; 2005. pp. 503–507.
7. Jung SE, Rha SE, Lee JM et-al. CT and MRI findings of sex cord-stromal tumor of the ovary. AJR Am J Roentgenol. 2005;185 (1): 207-15
8. Faria AM, Perez RV, Marcondes JA, Freire DS, Blasbalg R, Soares J, et al. A premenopausal woman with virilization secondary to an ovarian Leydig cell tumor. Nat Rev Endocrinol. 2011 Apr;7(4):240–5
9. Haider S.G., Pickartz H., Freundl G., Passia D., Demonstration of hydroxisteroid dehydrogenases and testosterone in the Sertoli-Leydig cell tumor (androblastoma) tissue of the human ovary: an enzyme histochemical and immunohistochemical study, Acta Anat., 121:170-173, 1985.
10. Costa M.J., Morris R.J., Wilson R., Judd R. Utility of immunohistochemistry in distinguishing ovarian Sertoli stromal cell tumors from carcinosarcomas, Hum.
Pathol., 23: 787-797, 1992
11. Riopel M.A., Perlman E.J., Seidman J.D., Kurman R.J., Sherman M.E., Inhibin and epithelial membrane antigen immunohistochemistry assist in the diagnosis of sex cordstromaltumors and provide clus to the histogenesis of hypercalcemic small cell carcinomas, Int. J. Gynecol. Pathol., 17: 46-53, 1998
12. Kommoss F., Oliva E., Bhan A.K., Young R.H., Scully R.E., Inhibin expression in ovarian tumors and tumorlike lesions: an immunohistochemical study, Mod. Pathol., 11: 656-664, 1998
13. Jung SE, Lee JM, Rha SE et-al. CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22 (6): 1305-25
14. Jung SE, Rha SE, Lee JM et-al. CT and MRI findings of sex cord-stromal tumor of the ovary. AJR Am J Roentgenol. 2005;185 (1): 207-15
15. KatariaSP.MishraK,DevG,Tandon R .Sertoli-Leydig cell tumour of ovary with heterologous element :a case report Indian J PatholMicrobiol 2005;48:493 –495
16. Metzinger D S,Webb M.J. Surgical Management of Sertoli-Leydig cell tumours of Ovary.CME J GynecolOncol 2002;7:140 -142
2. Dietrich JE, Kaplan A, Lopez H, Jaffee I. A case of poorly differentiated SertoliLeydig tumour of the ovary. J PediatrAdolesc Gynecol. 2004;17:49-52.
3. Lantzsch T, Stoerer S, Lawrenz K, Buchmann J, Strauss H-G, Koelbl H. Sertoli-Leydig cell tumour. Arch Gynecol Obstet. 2001;264:206-208. Abstract
4. Mathur SR, Bhatia N, Rao IS, Singh MK.SertoliLeydig cell tumour with heterologous gastrointestinal epithelium: a case report. Indian J PatholMicrobiol. 2003;46:91-93. Abstract
5. Lenhard, Miriam; Kuemper, Caroline; Ditsch, Nina; Diebold, Joachim; Stieber, Petra; Friese, Klaus; Burges, Alexander (2007). "Use of novel serum markers in
clinical follow-up of Sertoli–Leydig cell tumours". Clinical Chemistry and Laboratory Medicine45 (5): 657–61.
6. Colombo Ni, Parma Ga. Ovarian sex cord-stromal tumors. In: Gershenson DM, Mcguire Mc, Gore M, Quinn MA, Thomas G, editors. Gynecologic Cancer. Elsevier; 2005. pp. 503–507.
7. Jung SE, Rha SE, Lee JM et-al. CT and MRI findings of sex cord-stromal tumor of the ovary. AJR Am J Roentgenol. 2005;185 (1): 207-15
8. Faria AM, Perez RV, Marcondes JA, Freire DS, Blasbalg R, Soares J, et al. A premenopausal woman with virilization secondary to an ovarian Leydig cell tumor. Nat Rev Endocrinol. 2011 Apr;7(4):240–5
9. Haider S.G., Pickartz H., Freundl G., Passia D., Demonstration of hydroxisteroid dehydrogenases and testosterone in the Sertoli-Leydig cell tumor (androblastoma) tissue of the human ovary: an enzyme histochemical and immunohistochemical study, Acta Anat., 121:170-173, 1985.
10. Costa M.J., Morris R.J., Wilson R., Judd R. Utility of immunohistochemistry in distinguishing ovarian Sertoli stromal cell tumors from carcinosarcomas, Hum.
Pathol., 23: 787-797, 1992
11. Riopel M.A., Perlman E.J., Seidman J.D., Kurman R.J., Sherman M.E., Inhibin and epithelial membrane antigen immunohistochemistry assist in the diagnosis of sex cordstromaltumors and provide clus to the histogenesis of hypercalcemic small cell carcinomas, Int. J. Gynecol. Pathol., 17: 46-53, 1998
12. Kommoss F., Oliva E., Bhan A.K., Young R.H., Scully R.E., Inhibin expression in ovarian tumors and tumorlike lesions: an immunohistochemical study, Mod. Pathol., 11: 656-664, 1998
13. Jung SE, Lee JM, Rha SE et-al. CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22 (6): 1305-25
14. Jung SE, Rha SE, Lee JM et-al. CT and MRI findings of sex cord-stromal tumor of the ovary. AJR Am J Roentgenol. 2005;185 (1): 207-15
15. KatariaSP.MishraK,DevG,Tandon R .Sertoli-Leydig cell tumour of ovary with heterologous element :a case report Indian J PatholMicrobiol 2005;48:493 –495
16. Metzinger D S,Webb M.J. Surgical Management of Sertoli-Leydig cell tumours of Ovary.CME J GynecolOncol 2002;7:140 -142
How to Cite
1.
Lakshmi Rathna, Nidhi Saluja, Anuradha. OVARIAN SERTOLI LEYDIG CELL TUMOUR: A RARE CASE OF SEX CORD STROMAL TUMOUR. Med. res. chronicles [Internet]. 2016Oct.31 [cited 2024May9];3(05):437-41. Available from: https://medrech.com/index.php/medrech/article/view/196
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Case Report
