CLINICAL SIGNIFICANCE OF T LYMPHOCYTE SUBSETS AND HLA-DR IN PERIPHERAL BLOOD OF PATIENTS WITH SEVERE PREECLAMPSIA

  • Wu Tie-jun, Zhang Li-na Intensive Care Unit, Liaocheng People's Hospital, Liaocheng, China
  • Kang Cui-Cui, Zou Xiu-li Intensive Care Unit, Liaocheng People's Hospital, Liaocheng, China
  • Zou Xiu-li Intensive Care Unit, Liaocheng People's Hospital, Liaocheng, China
  • Tian Hui Intensive Care Unit, Liaocheng People's Hospital, Liaocheng, China
  • Xiao Ting-fang Intensive Care Unit, Liaocheng People's Hospital, Liaocheng, China
Keywords: Severe Preeclampsia, Immunity, T lymphocyte subsets, HLA-DR

Abstract

Objective: To observe the variation of T lymphocyte subsets and human histocompatibility antigen (HLA-DR) in peripheral blood of patients with severe preeclampsia( SPE).

Method: Peripheral blood from 30 patients with SPE (SPE group), 30 healthy pregnant women (healthy pregnant group) and 18 healthy un-pregnant women (healthy un-pregnant group) was a collected. The percentage of CD4+T, CD8+T and HLA-DR in each group were compared by Flow cytometry (FCM).

Results: There was no difference in the expression of CD4+T in each group ((35.6±5.4)%VS (37.8±8.9), (35.6±5.4)%VS(37.1±9.6)%). The expression of CD8+T in SPE group was significantly higher than those in the healthy pregnant group ((32.1±7.4)% VS(26.9±7.7)%, P< 0.01) and in the healthy un-pregnant group ((32.1±7.4)% VS(25.4±7.6)%, P< 0.01). The expression of HLA-DR in SPE group was significantly lower than that in healthy pregnant group ((43.7±12.7)% VS(58.3±13.9)%; P< 0.01).

Conclusions: Higher expression of CD8+T was found in peripheral blood of SPE patients which lead to T lymphocyte subsets imbalance. The decrease of HLA-DR may contribute to the pathologic process of SPE.

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How to Cite
1.
Wu Tie-jun, Zhang Li-na, Kang Cui-Cui, Zou Xiu-li, Zou Xiu-li, Tian Hui, Xiao Ting-fang. CLINICAL SIGNIFICANCE OF T LYMPHOCYTE SUBSETS AND HLA-DR IN PERIPHERAL BLOOD OF PATIENTS WITH SEVERE PREECLAMPSIA. Med. res. chronicles [Internet]. 2017Feb.28 [cited 2021Oct.21];4(01):17-2. Available from: https://medrech.com/index.php/medrech/article/view/212
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Original Research Article