POSSIBLE PERIPHERAL LIPOLYTIC EFFECT OF CLOBENZOREX HYDROCHLORIDE IN PATIENTS WITH OBESITY

  • Cortés-Moreno Gabriela Y Laboratorio de Obesidad, Sección de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional, Av. Salvador Diaz Mirón y Plan de San Luis s/n, Col. Casco de Santo Tomas, 11340 Ciudad de México, México
  • Heald-H Adrian The School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, Manchester
  • Miliar-García Ángel Laboratorio de Obesidad, Sección de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional, Av. Salvador Diaz Mirón y Plan de San Luis s/n, Col. Casco de Santo Tomas, 11340 Ciudad de México, México
  • Morín-Zaragoza Raúl Academia Mexicana para el Estudio de la Obesidad. Palenque 130-4, Col. Narvarte 03020 Ciudad de México, México
  • Guerrero-Domínguez Rafae Laboratorio de Obesidad, Sección de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional, Av. Salvador Diaz Mirón y Plan de San Luis s/n, Col. Casco de Santo Tomas, 11340 Ciudad de México, México
  • Lara-Padilla Eleazar Laboratorio de Obesidad, Sección de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional, Av. Salvador Diaz Mirón y Plan de San Luis s/n, Col. Casco de Santo Tomas, 11340 Ciudad de México, México
Keywords: clobenzorex hydrochloride, drug treatment, obesity

Abstract

Introduction: It is well known that clobenzorex hydrochloride is an amine that inhibits appetite by its sympathomimetic action on the lateral hypothalamus. However, it has been reported that this drug also has a peripheral lipolytic effect, which has not been studied sufficiently. The aim of this study was to evaluate such lipolytic action in obese patients.

Methods: A controlled clinical trial was conducted with male and female patients having class I and II obesity and an age range of 30-60 years (n=33). Patients were randomized into two groups: the experimental group (n=16) received a single oral dose of 90 mg clobenzorex, and the control group (n=17) a placebo. Blood samples were taken at 0, 60, 120, 180 and 240 min post-administration to determine serum levels of free fatty acids (FFAs), glycerol, glucose, triglycerides, HDLcholesterol and LDL-cholesterol. The atherogenic index (AI) was calculated.

Results: Over the time of the study (0-240 min), the experimental group showed an increase in HDL-cholesterol (from 42.0 to 55.6 mg/dl; p=0.01), FFAs (from 0461 to 1009 mMol/l; p=0.01), and glycerol (from 0.123 to 0.170 mMol/lt; p=0.01). There was a significant decrease in AI (from 5.87 to 5.26; p=0.01). The placebo group showed a significant increase only in FFAs (from 0436 to 0824 mMol/lt; p=0.01) and a significant decrease in AI (from 4.51 to 4.05; p=0.01).

Conclusion: These results suggest that clobenzorex hydrochloride has peripheral lipolytic activity, which can be considered as an additional effect, synergistic with its central pharmacological mechanism.

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How to Cite
1.
Cortés-Moreno Gabriela Y, Heald-H Adrian, Miliar-García Ángel, Morín-Zaragoza Raúl, Guerrero-Domínguez Rafae, Lara-Padilla Eleazar. POSSIBLE PERIPHERAL LIPOLYTIC EFFECT OF CLOBENZOREX HYDROCHLORIDE IN PATIENTS WITH OBESITY. Med. res. chronicles [Internet]. 1 [cited 2022Jan.18];4(03):252-65. Available from: https://medrech.com/index.php/medrech/article/view/239
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Original Research Article