POSSIBLE PERIPHERAL LIPOLYTIC EFFECT OF CLOBENZOREX HYDROCHLORIDE IN PATIENTS WITH OBESITY
Introduction: It is well known that clobenzorex hydrochloride is an amine that inhibits appetite by its sympathomimetic action on the lateral hypothalamus. However, it has been reported that this drug also has a peripheral lipolytic effect, which has not been studied sufficiently. The aim of this study was to evaluate such lipolytic action in obese patients.
Methods: A controlled clinical trial was conducted with male and female patients having class I and II obesity and an age range of 30-60 years (n=33). Patients were randomized into two groups: the experimental group (n=16) received a single oral dose of 90 mg clobenzorex, and the control group (n=17) a placebo. Blood samples were taken at 0, 60, 120, 180 and 240 min post-administration to determine serum levels of free fatty acids (FFAs), glycerol, glucose, triglycerides, HDLcholesterol and LDL-cholesterol. The atherogenic index (AI) was calculated.
Results: Over the time of the study (0-240 min), the experimental group showed an increase in HDL-cholesterol (from 42.0 to 55.6 mg/dl; p=0.01), FFAs (from 0461 to 1009 mMol/l; p=0.01), and glycerol (from 0.123 to 0.170 mMol/lt; p=0.01). There was a significant decrease in AI (from 5.87 to 5.26; p=0.01). The placebo group showed a significant increase only in FFAs (from 0436 to 0824 mMol/lt; p=0.01) and a significant decrease in AI (from 4.51 to 4.05; p=0.01).
Conclusion: These results suggest that clobenzorex hydrochloride has peripheral lipolytic activity, which can be considered as an additional effect, synergistic with its central pharmacological mechanism.
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