EFFECT OF MALARIA INFECTION ON BLOOD PARAMETERS AND VIRAL LOAD IN HIV INFECTED CAMEROONIAN PATIENTS UNDER HAART: A HOSPITAL-BASED STUDY

  • Kamgain Mawabo Lugarde District hospital of Deido, Douala, Cameroon and Distant Production House University (DPHU)-Ecole doctorale, RD Congo
  • Assam Assam Jean-Paul Distant Production House University (DPHU)-Ecole doctorale, RD Congo and Faculty of Sciences, University of Douala, Douala, Cameroon
  • Kojom Foko Pradel Faculty of Sciences, University of Douala, Douala, Cameroon
  • Elanga Njille Emmanuel Distant Production House University (DPHU)-Ecole doctorale, RD Congo and Centre Pasteur du Cameroun, Yaoundé, Cameroon
  • Ewodo Symphorien Distant Production House University (DPHU)-Ecole doctorale, RD Congo and Douala General Hospital, Douala, Cameroon
  • Calixte Yadufashije Distant Production House University (DPHU)-Ecole doctorale, RD Congo
  • Kamga Henri Lucien Distant Production House University (DPHU)-Ecole doctorale, RD Congo and Faculty of Health Sciences, University of Bamenda, Bamenda, Cameroon
Keywords: Malaria, HIV, co-infection, Blood parameters, viral load, Cameroon

Abstract

Co-infections with malaria and HIV infection are common in Sub-Saharan countries. This study aimed at determining the effect of malaria infection on blood parameters and viral load of Cameroonian people living with HIV (PLWHIV) and under antiretroviral treatment. A cross sectional and prospective study took place at the District hospital of Deido. About, 8 mL of venous blood were obtained from each patient by venipuncture for performing complete blood count, thick blood smear and CD4 cells count. Sociodemographic data of participants were sought. In total, 723 patients were enrolled in the study with an average age of 39.49 ± 11.17 years old. The mean count of CD4 lymphocytes was 427 ± 257 (range: 6 - 1369 cells/µL). The prevalence of malaria was 16.7% (95%CI: 14.2%-19.6%). Hemoglobin and haematocrit were lower in malaria infected individuals (P-value < 0.0001). Viral loads were significantly higher in infected males compared to their uninfected counterparts (65195.20 ± 978.04 versus 540 ± 91.24 copies/µL; P-value < 0.0001). The risk of anemia was twofold and about threefold higher in males (OR = 2.28; 95%CI = 1.58 – 3.29; P-value < 0.0001) and malaria parasites infected individuals (OR = 2.85; 95%CI = 1.28 – 4.78; P-value < 0.0001) respectively. It is critical to take into account treatment of malaria episodes in PLWHIV during their management.

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How to Cite
1.
Kamgain Mawabo Lugarde, Assam Assam Jean-Paul, Kojom Foko Pradel, Elanga Njille Emmanuel, Ewodo Symphorien, Calixte Yadufashije, Kamga Henri Lucien. EFFECT OF MALARIA INFECTION ON BLOOD PARAMETERS AND VIRAL LOAD IN HIV INFECTED CAMEROONIAN PATIENTS UNDER HAART: A HOSPITAL-BASED STUDY. Med. res. chronicles [Internet]. 2017Jun.30 [cited 2022Aug.18];4(03):275-86. Available from: https://medrech.com/index.php/medrech/article/view/241
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Original Research Article