FINE NEEDLE ASPIRATION CYTOLOGY OF THE BREAST, COMPONENT OF A TRIPLE TEST: A REVIEW

  • Godstime I. Irabor Department of Pathology, Saba University School of Medicine, Saba Island, Dutch Caribbean, Netherlands
  • Dominic Akpan Department of Pathology, Saba University School of Medicine, Saba Island, Dutch Caribbean, Netherlands
  • Edoise M. Isiwele Department of Surgery, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria
  • Ayodele J. Omotoso Department of Pathology, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria
  • Godwin A. Ebughe Department of Pathology, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria
  • Martin A. Nnoli Department of Pathology, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria
Keywords: Fine needle, aspiration, cytology, triples test, breast, cytopathologist

Abstract

Background: Fine needle aspiration cytology (FNAC) is a type of interventional cytology. It is a clinicopathological procedure involving the collection of cells from a lesion using a fine needle and syringe. The breast/mammary gland is one of the commonest organs in the body which may develop lesions/lumps requiring fine needle aspiration cytology. This test is ideally done as part of a triple test following clinical examination and imaging studies. Therefore the approach in fine needle aspiration cytology is multidisciplinary. This procedure has a high sensitivity and specificity in addition to several other advantages including the good turn round time, minimal side effect and cost of the procedure when compared to histology. It has proven to be a really effective method in the diagnosis of breast cancer when used as part of the triple test. The result is more accurate when it is done by an experienced cytopathologist. The complications from this procedure are rare and include infection, hematoma, pneumothorax and dissemination of the tumor.

Aim/Objective: To do a literature review on fine needle aspiration cytology as part of a triple test

Conclusion: Fine needle aspiration cytology has been an effective tool for screening for breast cancer for many years and it is very accurate when combined with clinical finding and imaging.

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References

1. McManus DT, Anderson NH. Fine needle aspiration cytology of the breast. Curr Diagnostic Pathol. 2001;7 (4):262– 71.
2. Wypij JM. Getting to the point: Indications for fine-needle aspiration of internal organs and bone. Topics in Companion Animal Medicine. 2011. p.77–85.
3. Westenend PJ, Jobse C. Evaluation of fine-needle aspiration cytology of breast masses in males. [Internet]. Cancer. 2002. p. 101–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11954020
4. Unit CE, Kingdom U. Ovarian cancer, and body size: individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies. PLoS Med [Internet]. 2012; 9(4): e1001200. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3317899&tool=pmcentrez&rendertype=abstract
5. Kocjan G. Fine needle aspiration cytology: Diagnostic principles and dilemmas. Fine Needle Aspiration Cytology: Diagnostic Principles and Dilemmas. 2006. 1-239 p.
6. Australian National Breast Cancer Centre. Breast fine needle aspiration cytology and core biopsy: a guide for practice. Breast. 2004;www.nbcc.org.au.
7. Van Rijk MC, Deurloo EE, Nieweg OE, Gilhuijs KG a, Peterse JL, Rutgers EJT, et al. Ultrasonography and fine-needle aspiration cytology can spare breast cancer patients unnecessary sentinel lymph node biopsy. Ann Surg Oncol. 2006;13(1):31–5.
8. MacNeill M, Arnott I, Thomas J. Fine needle aspiration cytology is a valuable adjunct to axillary ultrasound in the preoperative staging of breast cancer. J Clin Pathol. 2011;64(1):42–6.
9. Patel JJ, Gartell PC, Guyer PB, Herbert A, Taylor I. Use of ultrasound localization to improve results of fine needle aspiration cytology of breast masses. J R Soc Med. 1988;81(1):10–2.
10. Howat AJ. Why pathologists should take needle aspiration specimens. Cytopathology. 1995;6(6):419.
11. Moore KL, Dalley AF. Clinically Oriented Anatomy. Lippincott Williams & Wilkins; 2006. p. 106–12.
12. Mills SE. Histology for Pathologists, 3rd Ed. Lippincott and Wilkins; 2007.
13. Mohan H. Pathology quick reviews and MCQs. 6th ed. Mohan H, editor. New Delhi: Jaypee Brothers Medical Publishers; 2010. 212-226 p.
14. Kalber B. Breaking bad news - whose responsibility is it? Eur J Cancer Care (Engl). 2009;18(4):330.
15. Litherland JC. Should fine needle aspiration cytology in breast assessment be abandoned? Clinical Radiology. 2002. p. 81–4.
16. Orell SR. Pitfalls in fine needle aspiration cytology. Cytopathology. 2003. p. 173–82.
17. Chen KT. Fine needle aspiration cytology of squamous cell carcinoma of the breast. Acta Cytol. 2013;34(5):664–8.
18. Yugawa T, Kiyono T. Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins. Rev Med Virol. 2009;19(2):97–113.
19. Willems SM, van Deurzen CHM, van Diest PJ. Diagnosis of breast lesions: fine-needle aspiration cytology or core needle biopsy? A review. J Clin Pathol. 2012;65(4):287–92.
20. Lever J V, Trott P a, Webb a J. Fine needle aspiration cytology. J Clin Pathol. 1985;38(1):1–11.
21. Pieter J. Westenend, Ali R. S, Hannie J. C. B, Sik J. Liem, A Comparison of Aspiration Cytology and Core Needle Biopsy in the Evaluation of Breast Lesions, Cancer (Cancer Cytopathology), 2001 / Vol 93(2): 146-150
22. Daramola AO, Odubanjo MO, Obiajulu FJ, Ikeri NZ, Aina A, Banjo F. Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution. 2015;2015.
23. Ebughe GA, Omoronyia OE, Ugbem TI, Usoro N, Ushie DE. An Audit of Fine Needle Aspiration Cytology Diagnosis of Breast Lesions in Calabar, Nigeria. 2016;19(1):1–8.
24. Sun W, Li a, Abreo F, TurbatHerrera E, Grafton WD. Comparison of fine-needle aspiration cytology and core biopsy for diagnosis of breast cancer. Diagn Cytopathol [Internet]. 2001;24(6):421–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11391825
25. Gupta M, Gupta S, Gupta VB. Correlation of fine needle aspiration cytology with histopathology in the diagnosis of a solitary thyroid nodule. J Thyroid Res. 2010;2010:379051.
26. Barnett MM. Effect of breaking bad news on patients’ perceptions of doctors. J R Soc Med [Internet]. 2002;95(7):343– 7. Available from: http://www.NCBI.nlm.nih.gov/pubmed/12091508\n http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1279938/pdf/0950343.pdf
27. Konstantis A, Extra T. Breaking Bad News in Cancer Patients. Indian J Palliat Care [Internet]. 2015;21(1):35–8. Available from: http://ezproxy.usherbrooke.ca/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=2012891693&site=ehostlive
28. Kaplan M. SPIKES: A framework for breaking the bad news to patients with cancer. Clin J Oncol Nurs. 2010;14(4):514–6.
29. Paul CL, Clinton-McHarg T, Sanson-Fisher RW, Douglas H, Webb G. Are we there yet? The state of the evidence base for guidelines on breaking the bad news to cancer patients. Eur J Cancer. 2009;45(17):2960–6.
30. Vandekieft GK. Breaking bad news. American Family Physician. 2001. p. 1975–8.
How to Cite
1.
Godstime I. Irabor, Dominic Akpan, Edoise M. Isiwele, Ayodele J. Omotoso, Godwin A. Ebughe, Martin A. Nnoli. FINE NEEDLE ASPIRATION CYTOLOGY OF THE BREAST, COMPONENT OF A TRIPLE TEST: A REVIEW. Med. res. chronicles [Internet]. 2017Oct.31 [cited 2024Dec.22];4(05):495-00. Available from: https://medrech.com/index.php/medrech/article/view/265
Issue
Vol. 4 No. 05 (2017): Sep-Oct
Section
Review Article