POSTMORTEM DIAGNOSIS OF PULMONARY RELAPSE OF LANGERHANS CELL HISTIOCYTOSIS ON FINE NEEDLE ASPIRATION CYTOLOGY
Keywords:
Langerhans cell histiocytosis, Postmortem, Fine needle aspiration cytology, relapse
Abstract
Langerhans cell histiocytosis (LCH) is an unusual disease where pathologic Langerhans cells accumulate in various organs. Multiorgan involvement and the young age of presentation are associated with frequent relapses and high mortality. We report a three-year-old girl, presenting with fatal pulmonary relapse following initial treatment, diagnosed on postmortem fine needle aspiration cytology. This case emphasizes the importance of cytology in the diagnosis of LCH.
Downloads
Download data is not yet available.
References
1. Satter EK, High WA. Langerhans Cell Histiocytosis: A Review of the Current Recommendations of the Histiocyte Society. Pediatr Dermatol. 2008 May-Jun;25(3):291-5.
2. Nakhla H, Jumbelic MI. The sudden death of a patient with pulmonary Langerhans cell histiocytosis. Arch Pathol Lab Med. 2005 Jun; 129(6):798-9.
3. Wong CY, Law GTS, Wong KY, Shum TT, Yip HLK. A case of Langerhans’ cell histiocytosis of the lung presenting with hemoptysis. Hong Kong Med J 2004; 10(1):49-51.
4. Kumar N, Sayed S, Vinayak S. Diagnosis of Langerhans Cell Histiocytosis on Fine Needle Aspiration Cytology: A Case Report and Review of the Cytology Literature. Pathology Res Int. 2011 Jan 20; 2011:439518.
5. Kilpatrick SE. Fine needle aspiration biopsy of Langerhans cell histiocytosis of bone: are ancillary studies necessary for a “definitive” diagnosis? Acta Cytologica 1998; 42(3);820–3.
6. Favara BE, Feller AC, Pauli M, Jaffe ES, Weiss LM, Arico M, Bucsky P, Egeler RM, Elinder G, Gardner H, Gresik M, Henter JI, Imashuku S, Janka-Schaub G, Jaffe R, Ladisch S, Nezelof C, Pritchard J. Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic/ Reticulum Cell Proliferations. Reclassification Working Group of the Histiocyte Society. Med Pediatr Oncol. 1997 Sep; 29(3):157-66.
7. Gee SN, Huang JT, Schmidt BA, Gellis SE. Rapidly Fatal Multiorgan Langerhans Cell Histiocytosis in a Neonate. Pediatr Dermatol. 2012 Dec 26.
2. Nakhla H, Jumbelic MI. The sudden death of a patient with pulmonary Langerhans cell histiocytosis. Arch Pathol Lab Med. 2005 Jun; 129(6):798-9.
3. Wong CY, Law GTS, Wong KY, Shum TT, Yip HLK. A case of Langerhans’ cell histiocytosis of the lung presenting with hemoptysis. Hong Kong Med J 2004; 10(1):49-51.
4. Kumar N, Sayed S, Vinayak S. Diagnosis of Langerhans Cell Histiocytosis on Fine Needle Aspiration Cytology: A Case Report and Review of the Cytology Literature. Pathology Res Int. 2011 Jan 20; 2011:439518.
5. Kilpatrick SE. Fine needle aspiration biopsy of Langerhans cell histiocytosis of bone: are ancillary studies necessary for a “definitive” diagnosis? Acta Cytologica 1998; 42(3);820–3.
6. Favara BE, Feller AC, Pauli M, Jaffe ES, Weiss LM, Arico M, Bucsky P, Egeler RM, Elinder G, Gardner H, Gresik M, Henter JI, Imashuku S, Janka-Schaub G, Jaffe R, Ladisch S, Nezelof C, Pritchard J. Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic/ Reticulum Cell Proliferations. Reclassification Working Group of the Histiocyte Society. Med Pediatr Oncol. 1997 Sep; 29(3):157-66.
7. Gee SN, Huang JT, Schmidt BA, Gellis SE. Rapidly Fatal Multiorgan Langerhans Cell Histiocytosis in a Neonate. Pediatr Dermatol. 2012 Dec 26.
How to Cite
1.
Mathew M, Nayal B, Manohar C, Parveen S. POSTMORTEM DIAGNOSIS OF PULMONARY RELAPSE OF LANGERHANS CELL HISTIOCYTOSIS ON FINE NEEDLE ASPIRATION CYTOLOGY . Med. res. chronicles [Internet]. 2014Dec.26 [cited 2024May9];1(2):173-6. Available from: https://medrech.com/index.php/medrech/article/view/28
Section
Case Report
