AN INCIDENTIAL FINDING OF HYPERCALCEMIA IN A PATIENT WITH ACUTE MYLOID LEUKAEMIA
Keywords:
hypercalcemia, leukemia, hyperparathyroidism, vitamin D
Abstract
Hypercalcemia complicating leukemia is a rare, but well-recognized finding. Few case reports have been documented in various journals. The etiology in most cases is not fully understood; however, there is an established fact that there is a link with cytokine release. We report a case of a 65year-old man who presented with hypercalcemia, during the course of his illness. Possible causes of hypercalcemia such as hyperparathyroidism, vitamin D intoxication, solid tumors, and ectopic parathyroid hormone production were excluded. From the case report, it is concluded that leukemia may be complicated by hypercalcemia and physicians should bear this in mind as they manage patients with leukemia.
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References
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2. Grauer A. Hypercalcemia associated with hematologic malignancies. Recent Results Cancer Res 1994;137: 114-21.
3. Ross Garret, Brian GM, Glenn Nedwin; Allison G. Products of lymphotoxin; a Bone-Resorbing Cytokine by cultured myeloma cell. N Eng J. Med. 1987: 317:
526-32.
4. Burtis CA, Ashwood ER, Bruns DE. Tietz Textbook of Clinical Chemistry and molecular diagnostics.4th ed.(editors), 2008:1892-1894.
5. Seccarecia D. Cancer-related hypercalcemia. Can Fam Physician. 2010; 56(3):244-246
6. Robert Knisley. Hypercalcemia associated with leukemia. Arch Intern Med. 1966; 18(1):14-16.
7. Bernard RB, Brigitte JP, Jen-Luc S, Odile K. Leukemia-associated hypercalcemia in a 10year old boy: effectiveness of aminohydroxypropylidine bisphosphonate.
Pediatric Nephrology. 1990; vol. 4, Issue 5, pp 500-511.
8. Muna Q, Ibrahim A, Rodolph P. Hypercalcemia in pediatric acute megakaryocytic leukemia: case report and review of the literature. Journal of pediatric hematology/oncology. 2009: 31(5): 373-376.
9. Stewart AF, Gewirtz AM, Vigney A, Hoffman R: Hypercalcemia complicating acute myelogenous leukemia: a syndrome of multiple etiologies. British Journal of
Haematology 1983;54(1): 133-41.
10. Todo S, Imashuku S, Inoda H, Yamanaka H, Hibi S. Hypercalcemia in a case of childhood Acute lymphoblastic leukemia – Jpn J Clin Oncol. 1987:17(4):357-62.
11. Laffan MA. Hypercalcemia in a Tcell adult lymphocytic leukemia – report of two cases. Case. J. Clin Path. 1986:39 (10): 1143-1146).
How to Cite
1.
Ekpe EL, Osuji KC. AN INCIDENTIAL FINDING OF HYPERCALCEMIA IN A PATIENT WITH ACUTE MYLOID LEUKAEMIA. Med. res. chronicles [Internet]. 2018Feb.28 [cited 2024Dec.22];5(01):78-0. Available from: https://medrech.com/index.php/medrech/article/view/291
Section
Case Report
