CARCINOMA OF UTERINE CERVIX WITH MULTIPLE SKULL METASTASES AS THE FIRST PRESENTATION OF RECURRENCE: A CASE REPORT

  • Praffulla Chandra Rai Senior Resident, Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow
  • Ajeet Kumar Gandhi Assistant Professor, Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow
  • Madhup Rastogi Professor and Head, Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow
  • Satyajeet Rath Senior Resident, Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow
  • Sambit Swarup Nanda Senior Resident, Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow
  • Harikesh Bahadur Singh Senior Resident, Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow
Keywords: Carcinoma cervix, calvarial metastasis, recurrent

Abstract

Carcinoma of cervix recurring as multiple skull metastasis is a very rare presentation. A 49-yearold woman, a diagnosed case of carcinoma cervix [International Federation of Gynecology and Obstetrics (FIGO) stage IB1] treated with radical hysterectomy presented with generalized seizures to us after 40 months of initial diagnosis. Contrast-enhanced computed tomography showed metastasis to left temporoparietal bone and left frontal bone. Biopsy from the left temporal lesion showed non-keratinizing squamous cell carcinoma. She was thus diagnosed as recurrent carcinoma cervix with multiple calvarial metastases with the controlled primary site. She received palliative radiotherapy to the entire skull. She further received 4 cycles of palliative chemotherapy with paclitaxel and carboplatin repeated every 3 weeks. However, she could not tolerate chemotherapy after 4 cycles owing to significant deterioration of performance status and expired after 12 months of diagnosis of metastasis.

Downloads

Download data is not yet available.

References

1. Hong JH, Tsai CS, Lai CH, Chang TC, Wang CC, Chou HH, et al. Recurrent squamous cell carcinoma of the cervix after definitive radiotherapy. Int J Radiat
Oncol Biol Phys 2004; 60:249–257
2. Disibio G, French SW. Metastatic patterns of cancers: results from a large autopsy study. Arch Pathol Lab Med 2008; 132:931–939
3. Thanapprapasr D, Nartthanarung A, Likittanasombut P, Na Ayudhya NI, Charakorn C, Udomsubpayakul U, et al. Bone metastasis in cervical cancer
patients over a 10-year period. Int J Gynecol Cancer 2010; 20:373-8
4. Zilberlicht A, Voldavsky E, Lavie O, Auslender R, Shai A. Prolonged survival in a patient with isolated skull recurrence of cervical carcinoma - Case report and
review of the literature. Gynecol Oncol Rep 2014;11:20-2
5. Kapali A, Kumar AS, Malathi M, Shamsundar SD. Carcinoma cervix with fat attenuating skull metastases. J Cancer Metastasis Treat 2016;2:228-30
6. Ahmadloo N, Bidouei F, Omidvari S, Ansari M, Mosalaei A, Mohammadianpanah M. Bony calvarium as the sole site of metastases in squamous cell carcinoma of the uterine cervix. Middle East J Cancer 2010; 1:185–188.
7. Abhishek A, Ouseph MM, Sharma P, Kamal V, Sharma M. Bulky scalp metastasis and superior sagittal sinus thrombosis from a cervical adenocarcinoma: an unusual case. J Med Imaging Radiat Oncol 2008; 52, 91–94.
8. Baid BL, Kumar L, Chander S, Rath GK, Kumar S, Kriplani A, et al. Bone metastases in the patients of carcinoma cervix. Indian J Cancer 1992;29:71-5.
9. Pasricha R, Tiwari A, Aggarwal T, Lal P. Carcinoma of the uterine cervix with isolated metastasis to the fibula and its unusual behavior: report of a case and review of the literature. J Cancer Res Ther 2006; 2:79–81.
How to Cite
1.
Praffulla Chandra Rai, Ajeet Kumar Gandhi, Madhup Rastogi, Satyajeet Rath, Sambit Swarup Nanda, Harikesh Bahadur Singh. CARCINOMA OF UTERINE CERVIX WITH MULTIPLE SKULL METASTASES AS THE FIRST PRESENTATION OF RECURRENCE: A CASE REPORT. Med. res. chronicles [Internet]. 2018Apr.30 [cited 2022Jun.27];5(2):126-30. Available from: https://medrech.com/index.php/medrech/article/view/296
Section
Case Report