MINERAL BONE DISORDERS IN NAÏVE CHRONIC KIDNEY DISEASE PATIENTS – A COHORT STUDY FROM A TERTIARY CENTRE IN SOUTH INDIA

  • M. Edwin Fernando Prof & Head, Department of Nephrology, Govt. Stanley Hospital, Chennai, India
  • Ishwarya Annamalai Senior Resident, Department of Nephrology
  • S A K Noor Mohammed Assistant Professor, Department of Nephrology
  • Thirumavalavan S Assistant Professor, Department of Nephrology
  • Chandramohan K Assistant Professor, Department of Nephrology
  • N D Srinivasa Prasad Assistant Professor, Department of Nephrology
Keywords: Chronic kidney disease, Mineral bone disorder, Noninvasive assessment

Abstract

Background: Highest rates of morbidity and mortality in chronic kidney disease (CKD) are encountered with its cardiovascular complications and Mineral Bone Disorders (MBD). MBD is now being recognized as a systemic disorder with far-reaching consequences on the quality of life and is no longer merely restricted to the histomorphometric findings in the bone biopsy.

Objective: Few studies to date are available on the pattern of mineral bone disorders in Indian CKD population. Our primary aim was to study the varied patterns of CKD mineral bone disorders in our center based on biochemical parameters.

Patients & Methods: Cross-sectional study involving 75 newly diagnosed patients with CKD stages G3, G4 & G5D. Patients were categorized into two groups based on their KDIGO CKD staging- Group A – CKD stages G3a, G3b, G4; Group B – CKD stage G5D. The biochemical markers of CKD-MBD, namely, serum calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone (PTH), and 25-hydroxyvitamin Vitamin D were measured.

Results: 24 patients were included in group A and 51 patients in group B. The most common underlying native kidney disease was chronic glomerulonephritis (41.3%), followed by diabetic nephropathy (37.3%) and chronic interstitial nephritis (21.3%). The mean age of our study population was 49.5 ± 22.9 years in group A and 54.1 ± 15.77 years in group B.

Conclusions: A higher prevalence of hyperphosphatemia, hypocalcemia and vitamin D deficiency was observed in our CKD cohort. Early identification and treatment of these mineral bone disorders are of paramount importance to prevent complications, retard disease progression and improve quality of life.

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How to Cite
1.
M. Edwin Fernando, Ishwarya Annamalai, S A K Noor Mohammed, Thirumavalavan S, Chandramohan K, N D Srinivasa Prasad. MINERAL BONE DISORDERS IN NAÏVE CHRONIC KIDNEY DISEASE PATIENTS – A COHORT STUDY FROM A TERTIARY CENTRE IN SOUTH INDIA. Med. res. chronicles [Internet]. 2018Apr.30 [cited 2024Mar.28];5(2):162-71. Available from: https://medrech.com/index.php/medrech/article/view/300
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Original Research Article