MALIGNANT PHYLLODES WITH OSTEOSARCOMATOUS DIFFERENTIATION – A CASE REPORT

  • Jegan Subramaniam Department of General Surgery, Kasturba Medical College, Manipal University, Manipal, India
  • Rajesh Parameshwaran Nair Department of General Surgery, Kasturba Medical College, Manipal University, Manipal, India
  • Bhavna Nayal Department of Pathology, Kasturba Medical College, Manipal University, Manipal, India
  • Lakshmi Rao Department of Pathology, Kasturba Medical College, Manipal University, Manipal, India
Keywords: Breast tumor, malignant phyllodes tumor, osteosarcomatous features, infiltrating ductal carcinoma

Abstract

Introduction: Malignant phyllodes tumor is a rare and aggressive neoplasm, which presents as a breast lump and is detected on routine examination in premenopausal women. Heterologous differentiation is uncommon in these tumors. Owing to its rare occurrence, very few treatment protocols have been formulated for these cases posing a surgical dilemma.

Presentation of Case: For a better understanding of the pathogenesis and prognosis of these tumors we discuss here the clinical profile of a 49-year-old lady with metastatic phyllodes tumor of the breast with osteosarcomatous differentiation.

Discussion: Malignant phyllodes with osteosarcomatous differentiation are highly aggressive and extremely rare constituting 1.3% of all breast cancers. It has been hypothesized that malignant change of metaplastic stromal results in these neoplasms.

Conclusion: To conclude, malignant phyllodes are a rare entity. Osteosarcomatous differentiation is almost unheard of and indicates an aggressive biological behavior. Accurate diagnosis and timely surgical management are essential to prevent the progression of the disease and improve survival.

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How to Cite
1.
Subramaniam J, Nair RP, Nayal B, Rao L. MALIGNANT PHYLLODES WITH OSTEOSARCOMATOUS DIFFERENTIATION – A CASE REPORT . Med. res. chronicles [Internet]. 2014Dec.26 [cited 2024May8];1(2):193-6. Available from: https://medrech.com/index.php/medrech/article/view/32
Issue
Vol. 1 No. 2 (2014): Nov-Dec
Section
Case Report

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