QUALITATIVE ANALYSIS OF CANDIDA ALBICANS AND KOILOCYTES IN ORAL POTENTIALLY MALIGNANT DISORDERS AND ORAL SQUAMOUS CELL CARCINOMA

  • Priyanka Singh Assistant Professor, Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, KGMU, Lucknow, UP, India
  • Sanjay Kumar Singh Reader , Sarjug Dental college and Hospital, Darbhanga, Bihar, India
  • Anil Singh Professor and Head, Department of Oral Pathology and Microbiology, Saraswati Dental College and Hospital, Lucknow, UP, India
  • Sujata Saxena Reader, Department of Oral Pathology and Microbiology, Seema Dental College, Rishikesh
  • Shikha Saxena Associate Professor, Department of Oral Pathology and Microbiology, RUHS College of Dental Sciences, Jaipur, India
  • Pradakshana Vijay Senior Resident, Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, KGMU, Lucknow, UP, India
Keywords: Candida albicans, candidal hyphe, koilocytes, premalignant, carcinogenesis

Abstract

Fungal and viral infections especially Candida albicans and Koilocytes (Human papilloma virus altered cells) in premalignant and malignant lesions when compared to normal mucosa might indicate the contribution of these microorganisms in carcinogenesis.

Aim: To assess the frequency of Candida albicans and koilocytes in different oral lesions; to compare results with the Control group and to study the clinical significance of Candida infection and Koilocytes in different oral lesions.

Materials and method: Study was performed in the Department of Oral Pathology and Microbiology after getting approval by the Ethical Committee of the institution. 30 patients for each of above mentioned clinically diagnosed lesions were randomly selected during 2008-2009. Control group of 30 patients {same for each lesion} was selected from patients who had to undergo minor oral surgical procedures. Smears were obtained from the selected site and were stained with PAS stain to check for presence or absence of Candida hyphae. Also, an incisional biopsy of the lesion was performed: one section was stained with H & E stain for koilocytes and other with PAS stain for presence or absence of Candidal hyphae.

Results: Incidence of Candida albicans positivity in smear was significantly higher in Oral squamous cell carcinoma group as compared to other groups (p<0.05). Presence of Koilocytes in these lesions was non- significant.

Conclusion: Linear relationship of Candida with the transformation of premalignant lesions and conditions to malignant lesions. Higher incidence of Koilocytes in premalignant and malignant lesions, when compared to normal mucosa, indicates the contribution of HPV viruses in carcinogenesis.

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How to Cite
1.
Priyanka Singh, Sanjay Kumar Singh, Anil Singh, Sujata Saxena, Shikha Saxena, Pradakshana Vijay. QUALITATIVE ANALYSIS OF CANDIDA ALBICANS AND KOILOCYTES IN ORAL POTENTIALLY MALIGNANT DISORDERS AND ORAL SQUAMOUS CELL CARCINOMA. Med. res. chronicles [Internet]. 2018Dec.31 [cited 2024Nov.24];5(6):412-20. Available from: https://medrech.com/index.php/medrech/article/view/333
Issue
Vol. 5 No. 6 (2018): Nov-Dec
Section
Original Research Article