ACROMEGALY AND ULCERATIVE COLITIS – A RARE ASSOCIATION
Keywords:
Ulcerative colitis, Acromegaly
Abstract
Acromegaly results from excessive growth hormone (GH) and is easily diagnosed in patients who present with typical clinical features like macrognathia, field loss, and enlargement of appendages. It is associated with a number of Gastrointestinal complications like colonic polyps and neoplasia. Ulcerative colitis (UC) is an immune-mediated inflammatory bowel disease of with multitude of extra-intestinal manifestations but has never been described in association with Acromegaly. We report two cases of the simultaneous affliction of Acromegaly and ulcerative colitis.
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References
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10. Pucilowska JB, McNaughton KK, Mohapatra NK, Hoyt EC, Zimmermann EM, Sartor RB. IGF-I and procollagen alpha (I) are coexpressed in a subset of mesenchymal cells in active Crohn’s disease. Am J Physiol Gastrointest Liver Physiol. 2000;279: G1307-G1322.
2. Wassenaar MJE, Cazemier M, Biermasz NR, Pereira AM, Roelfsema F, Smit JWA. “Acromegaly is associated with an increased prevalence of colonic diverticula: a case-control study,” J. Clin Endocrinol Metab 2010;95(5):2073–2079.
3. Bogazzi F, Ultimieri F, Raggi F et al., “Changes in the expression of the peroxisome proliferator activated receptor gamma gene in the colonic polyps and colonic mucosa of acromegalic patients”. J Clin Endocrinol Metab 2003;88(8):3938.
4. Lois K, Bukowczan J, Perros P, Jones S, Gunn M, James RA. The role of colonoscopic screening in acromegaly revisited: a review of current literature and practice guidelines. Pituitary 2015;18(4):568-574
5. Magro F, Gionchetti P, Eliakim R, Ardizzone S, Armuzzi A, Barreiro-de Acosta M. Third European Evidencebased Consensus on Diagnosis and Management of lcerative Colitis. Part 1: Definitions, Diagnosis, Extraintestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileoanal Pouch Disorders. J Crohns
Colitis 2017;11(6):649–670
6. Levine JS, Burakoff R. Extraintestinal manifestations of inflammatory bowel disease. Gastroenterol Hepatol (NY) 2011;7:235-241.
7. Agouridis AP, Elisaf M, Milionis HJ. An overview of lipid abnormalities in patients with inflammatory bowel disease. Ann Gastroenterol 2011;24:181-187.
8. Hudson M, Flett G, Sinclair TS, Brunt PW, Templeton A, Mowat NA. Fertility and pregnancy in inflammatory bowel disease. Int J Gynecol Obstet 1997;58:229-237.
9. Giovannucci E. Insulin, insulin-like growth factors, and colon cancer: a review of the evidence. J Nutr. 2001;131:3109S-3120S.
10. Pucilowska JB, McNaughton KK, Mohapatra NK, Hoyt EC, Zimmermann EM, Sartor RB. IGF-I and procollagen alpha (I) are coexpressed in a subset of mesenchymal cells in active Crohn’s disease. Am J Physiol Gastrointest Liver Physiol. 2000;279: G1307-G1322.
How to Cite
1.
Atul Jha, Sachin Yadav, Vishal Jha, Gauri Jha. ACROMEGALY AND ULCERATIVE COLITIS – A RARE ASSOCIATION. Med. res. chronicles [Internet]. 2018Dec.31 [cited 2024Nov.24];5(6):458-60. Available from: https://medrech.com/index.php/medrech/article/view/339
Section
Case Study
