DETERMINATION OF ACUTE AND SUBACUTE TOXICITY OF SIX PLANT EXTRACTS
Abstract
Determining the toxicity of a plant extract is an important preliminary step, depending on which the therapeutic dose is adjusted. In the current study we proposed to test acute and subacute toxicity for six vegetal extracts using swiss albino healthy mice: Tragopogon pratensis, Dorycnium pentaphyllum subsp herbaceum, Acanthus balcanicus, Tamarix ramosissima, Carduus acanthoides compative with Vaccinium myrtillus (bilberry). The acute toxicity study revealed the lack of toxicity for the tinctures Acanthi balcanici herba, Dorycnii pentaphylli herba, Tragoponis pratensis folium, Tamaricis ramosissimae folium et flos, Myrtilli fructus, even at the gavage dose of 5 g / kg and the toxicity of tincture Cardui acanthoiditis folium, at a dose of 4g / kg. The subacute toxicity study demonstrates the lack of toxicity for all tinctures studied at the 400 mg / kg dose by gavage, a dose representing 1/10 of the dose that is supported by all animals in determining acute toxicity.
Downloads
References
2. Frank A, Clinical toxicology, Principles and mechanisms, (21):245 ˗246, 2005.
3. K.Z., Darah I., Chen Z., et al., Acute and Subchronic Toxicity Study of Euphorbia hirta L. methanol Extract in rats, BioMed Research International, 2013.
4. Subramanion L.J., Zakaria Z., Chen Z., et al., Acute oral toxicity of methanolic seed extract of Cassia fistula in mice, Molecules, (16):5268-5282; 2011.
5. A Guide toThe Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
6. Jaijoz K, Vannasiri S, Pizabhan P et al., Acute and subchronic toxicity study of the water extract from the fruits of Piper chaba hunter in rats, International Journal of Applied Research in Natural Products, 3 (4):29-35, 2011
