Association between proinsulin and cardiovascular events
Abstract
Aim: Coronary artery disease (CAD) still remains an important cause of death in spite of all advances in treatment. There are many risk factors for CAD. The aim of the present study was to evaluate the effect of of-of proinsulin on cardiovascular morbidity and mortality in nondiabetic coronary artery disease.
Material & Method: Nondiabetic 38 (8 female, 30 male) patients diagnosed with the acute coronary syndrome (ACS) admitted to coronary ICU of Haseki Training and Investigation Hospital and 21 control cases (9 female, 12 male) without diabetes and any cardiovascular disease were included in the present study. Proinsulin and other biochemical parameters of the patients were recorded. Five years later, among patients with the acute coronary syndrome (ACS), those who have recurring ACS and those who do not have were compared in terms of proinsulin and other biochemical parameters.
Results: There was no significant difference between acute coronary syndrome patients and controls with regard to proinsülin, Proinsulin /İnsulin ratio, and HOMA-IR values. However, a significant difference was found in age and glucose/insulin ratio. Respectively p=0.017, p=<0.001. After five years of follow up, significant difference was found between ACS patients who experienced cardiac event again and those who did not do so in terms of systolic blood pressure and proinsulin levels. Respectively p=0.013, p=0.031. No statistically significant difference was found in other parameters.
Conclusion: No significant difference was found between patients with ACS and control groups with respect to proinsulin levels. p=0.072. However, after five years of follow up, proinsulin levels were found to be high (p=0.031 )in the group who reexperienced cardiac events, suggesting that proinsulin may be a marker or risk factor of cardiovascular risk in the long term.
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References
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