Mean platelet volume as a measure of alveolar hypoventilation consequent to chronic nasal obstruction
Abstract
Nasal obstruction is a common presenting symptom in everyday rhinological practice. The chronic nasal obstruction causes upper respiratory tract resistance further leading to chronic hypoxia because of alveolar hypoventilation1, 2. MPV is associated with the function and activation of platelets and used as a marker of hypoxemia3. This prospective study conducted in the Department of Otorhinolaryngology and Head and neck surgery Vinayaka Missions Kirupananda Variyar Medical College, Salem on 30 patients with chronic nasal obstruction with 30 healthy control group. This study is to determine whether MPV values are elevated in patients with chronic nasal obstruction compared to healthy controls. The study also compares the Peak expiratory flow rate (PEFR) of nasal airflow between cases and controls. The diagnosis was based on anterior rhinoscopy and diagnostic nasal examination. In the present study deviated nasal septum was commonest followed by nasal polyps.MPV values are increased in all age groups compared to controls. The study also shows PEFR is decreased in cases compared to controls.
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References
Nagata Y et al (2003) Proplatelet formation of megakaryocytes is triggered by autocrine estradiol. Genes Dev 17:2864–2869
Toryila J.E. et al Study of nasal septal deviation in Curitiba, Science World Journal Vol 4 (No 1) 2009
Kamath P et al (2001) Platelet activation: assessment and quantification
Giles C (2008) Platelet count and mean platelet volume. Br J Haematol 48(1):31–37
Health research and foundation.org-MPV Blood Test Results Explained, Dec 20, 20135791
Gasparyan AY et al (2011) Mean platelet volume: a link between thrombosis and inflammation. Curr Pharm Des 17:47–58
Leader A et al (2012) Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med. 44(8):805–816
Bath PM et al (1993) The routine measurement of platelet size using sodium citrate alone as the anticoagulant. Thromb Haemost 70:687–690
Francoise L et al (2012) Leukotriene B4 activation and atherosclerosis in obstructivesleep apnoea. J Lipid Res 53(9): 1944– 1951
Bain BJ (1985) Platelet Count and Platelet Size in Males and Females. Scand J Haematol 35(1):77–79
Belic´ B, Andric´ V. Importance of active anterior rhinomanometry. Srp Arh Celok Lek 2002; 130 (suppl 1):33–6
Hanif J, Jawad SS, Eccles R. A study to assess the usefulness of a portable spirometer to quantify the severity of nasal septal deviation. Rhinology 2003;41:11–15
Schumacher MJ. Nasal congestion and airway obstruction: the validity of available objective and subjective measures. Curr Allergy Asthma Rep 2002;2:245–51
Adriana et al (2005) Prevalence of nasal septal deviation in Curitiba, Brazil, Intnatl Arch Otolaryngol Vol.9, Num. 4–Oct/Dec
Rappai M, Collop N, Kemp S, et al. The nose and sleep-disordered breathing: what we know and what we do not know. Chest 2003; 124:2309 Y2323
Olson EJ, Park JG, Morgenthaler TI. Obstructive sleep apnea-hypopnea syndrome. Prim Care 2005; 32:329Y359
Francoise L et al (2012) Leukotriene B4 activation and atherosclerosis in obstructive sleep apnoea. J Lipid Res 53(9): 1944– 1951
Stevens RF, Alexander MK (1977) A sex difference in the platelet count. Br J Haematol 37:295–300
Ulivi et al Age- And sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects’ data. PLoS ONE
Lance MD et al (2012) Mean platelet volume as a diagnostic marker for cardiovascular disease: Drawbacks of preanalytical conditions and measuring techniques. Clin and Appl Thromb Hemost 18(6):561–568
Leader A et al (2012) Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med. 44(8):805–816
Boos CJ et al (2008) The effects of coronary artery disease severity on timedependent changes in platelet activation indices in stored whole blood. J Thromb Thrombolysis. 25: 135–140
Kamath P et al (2001) Platelet activation: assessment and quantification. Eur Heart J 22:1561–71
Masanori S et al (2014) Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population 25(3):202–206.
Varol E et al (2010) Mean platelet volume is increased in patients with severe obstructive sleep apnea. Scand J Clin Lab Invest. 70(7):497–502
Francoise L et al (2012) Leukotriene B4 activation and atherosclerosis in obstructive sleep apnoea. J Lipid Res 53(9): 1944– 1951
Belic´ B, Andric´ V. Importance of active anterior rhinomanometry. Srp Arh Celok Lek 2002;130(suppl 1):33–6
Jang JY et al (2008) Classification of the deviated nose and its treatment. Arch Otolaryngol Head Neck Surg 134(3):311– 315.
Guyuron B, Uzzo C, Scull H (1999) A practical classification of septonasal deviation and an effective guide to septal surgery. Plast Roconstr Surg 104:2202–2209
Jin HR, Lee JY, Jung WJ. (2007) New description method and classification system for septal deviation. J Rhinol 14(1):27–31
Janardhan Rao J, Vinaykumar EC, Ram Babu K, et al. (2005) Classification of nasal septal deviation—relation to sinonasal pathologies. Indian J Otolaryngol Head Neck surgery 57(3): 199–201
Sikandar Hussain, “PEFR in cement pipe factory workers in relation to smoking”.Indian J Physiol Pharmacol 2000; 44(3):371-372
Min YG, Jung HW, Kim CS. Prevalence study of nasal septal deformities in Korea: results of a nation-wide survey. Rhinology 1995; 33:61–5
Fidan V, Aksakal E (2011) Impact of septoplasty on pulmonary artery pressure in patients with a markedly deviated septum. J Craniofac Surg 22:1591–1593.
Suzina AH, Hamzah M, Samsudin AR. Objective assessment of nasal resistance in patients with nasal disease. J Laryngol Otol 2003; 117:609–13.
