The odontogenic Keratocyst; evolution of treatment modalities and recurrence rates
Abstract
The odontogenic keratocyst (OKC) is considered one of the more aggressive cysts due to its high recurrence rate, expressed histopathologically by a delicate, friable wall containing small satellite cysts which is often difficult to enucleate from the bone in toto. First described by Philipsen in 1956, this particular entity has evoked much discussion and debate in terms of the treatment options and recurrence rates, in literature. Numerous surgical modalities have been practiced including decompression, marsupialization, enucleation with or without adjunct (such as Carnoy’s solution or cryotherapy) and resection. Having been classified as a cyst of odontogenic origin for over five decades, the designation changed from a cyst to an odontogenic tumour in 2005, and reversed back to a cyst in 2017. Approximately 11 % of all cysts of the maxillofacial region are comprised of odontogenic keratocysts and it is located most commonly in the mandibular posterior region. This paper aims to review the overall recurrence rate of the OKC in relation to specific treatment methods.
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References
Phillipsen H. On keratocysts in the jaws. Tandleagebladet. 1956;60:963.
Maurette PE, Jorje J, de Moraes M. Conservative treatment of odontogenic keratocyst: a preliminary study. J Oral Maxillofac Surg. 2006; 64(3):379–383.
Brown RM. The odontogenic keratocyst: clinical aspects. Br Dent J. 1970; 128(5): 228–231.
Brannon RB. The odontogenic keratocyst. A clinicopathologic study of 312 cases. Part 1. Clinical features. Oral Surg Oral Med Oral Pathol. 1976;42(1):54–72.
Rogerson KC: Gorlin’s syndrome: An update on diagnosis and management. Oral Maxillofac Clin North Am 3:155, 1991
Stoelinga, P. J. W., & Bronkhorst, F. B. (1988). The incidence, multiple presentation and recurrence of aggressive cysts of the jaws. J Craniomaxillofac Surg,16, 184–195.
Marker P, Brondum N, Clausen PP, et al: Treatment of large odontogenic keratocyst by decompression and later cystectomy: A long–term follow-up and a histologic study of 23 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82:122, 1996
Williams TP, Connor FA Jr: Surgical management of odontogenic keratocyst: Aggressive approach. J Oral Maxillofac Surg 3:329, 1997
Morgan TA, Burton CC, Qian F. A retrospective review of treatment of the odontogenic keratocyst. J Oral Maxillofac Surg 2005;63:635-9.
Jung YS, Lee SH, Park HS. Decompression of large odontogenic keratocysts of the mandible. J Oral Maxillofac Surg 2005; 63:267-71.
Bataineh AB, al Qudah M. Treatment of mandibular odontogenic keratocysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:42-7.
Schmidt B.L. The use of liquid nitrogen cryotherapy in the management of the odontogenic keratocyst. Oral Maxillofac. Surg. Clin. North Am. 2003;15:393
Schmidt B.L., Pogrel M.A. The use of enucleation and liquid nitrogen cryotherapy in the management of odontogenic keratocysts. J. Oral Maxillofac. Surg. 2001;59:720
Attenborough NR. Recurrence of an odontogenic keratocyst in a bone graft. Br J Oral Surg 1974: 12: 33–39.
Pogrel M. Decompression and marsupialization as a treatment for theodontogenic keratocyst. Oral Maxillofac. Surg. Clin. North Am. 2003;15:415.
Persson G. Remarkable recurrence of akeratocyst in a bone graft. Int J Oral Surg. 1973: 2: 69–76.
Zhang L, Sun ZJ, Zhao YF, Bian Z, Fan MW, Chen Z. Inhibition of SHH signaling pathway: Molecular treatment strategy of odontogenic keratocyst. Med Hypotheses. 2006; 67:1242–4
Degould, M. D., & Goldberg, J. S. Recurrence of an odontogenic keratocyst in a bone graft. Report of a case. Int. J. Oral Maxillofac. Surg. 1991; 20(1), 9–11.
Blanas N., Freund B., Schwartz M., Furst I.M. Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2000; 90:553.
Johnson NR, Batstone MD, Savage NW.Management and recurrence of keratocystic odontogenic tumor: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 116(4): e271-6.