Congenital cytomegalovirus infection with underlying neurological sequalae and status epilepticus simulating progressive cytomegalovirus encephalitis
Abstract
Congenital cytomegalovirus (CMV) infection is a leading cause of sensorineural hearing loss, mental retardation, developmental delay, seizure disorder, and neurological deficits with sequalae. Congenital CMV with central nervous system (CNS) manifestations usually have a permanent neurological disability resulting in an encephalopathy which is non-progressive but some infants with congenital CMV infection may progress or have persistent active brain inflammation resulting in progressive encephalopathy. Here we report a case of two years boy who presented with fever and status epilepticus with underlying CNS sequelae of congenital CMV infection which was a diagnostic challenge because of progressive neurologic symptoms simulating congenital cytomegalovirus progressive encephalitis. He was managed with intravenous fluids, oxygenation, Injection Ceftriaxone, and Acyclovir along with anti-seizure drugs. The child responded well without any new neurological deficit proving it was new-onset meningoencephalitis and not a progressive CMV encephalitis.
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References
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