PROGESTERONE INDUCED DIABETIC KETOACIDOSIS IN A YOUNG FEMALE: A CASE REPORT

  • Dr. P Suvarna MEM Resident, Department of Emergency Medicine, BGS Global Hospital, Bangalore, India
  • Dr. Mohammed Shabbir P Head of the Department, Department of Emergency Medicine, BGS Global Hospital, Bangalore, India
Keywords: Progesterone, Diabetic mellitus, Arterial blood gas analysis, Diabetic keto Acidosis

Abstract

A 25-year-old recently married female presented to our emergency department with a sudden the onset of breathlessness, pain abdomen, and fever from the past 1 hour. She was on tab progesterone 10 mg OD for the past 10 days to postpone her regular menstruation for her marriage. She was never been diagnosed to have diabetics mellitus in the past. On arrival at the emergency department, she was tachypoenic, severely dehydrated, and found to have elevated blood sugar levels. Arterial blood gas analysis showing severe wide anionic gap metabolic acidosis. She was diagnosed to have DKA. Managed as per standard DKA management protocol and was discharged from the hospital in euglycemic condition. Excess progesterone is known to impair both insulin sensitivity and secretion1 and deteriorate glycemic control and resulted in complications like Diabetic ketoacidosis / Hyperglycemia in previously Diabetic patients.

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References

1. Shugosasaki, Tetsuya kiyasuda, hideaki kaneto - Basal insulin requirements after progesterone treatment in type 1 diabetic pregnant women-inter med 52:259-262, 2013
2. Ekpebegh Chukwuma O, Benjamin longo- mbenza, Ernestoblanco- Blanco – Glycosylated hemoglobin is markedly elevated in new and known diabetes patients with hyperglycemic ketoacidosis. Afr Health Sci. Sep 2014(3)526-532
3. Patricaordonez, Maria Moreno, Anaalonso, Rebeca Fernandez, Fernandodiaz and Celestinogonzalez – Insulin sensitivity in streptozotocin-induced diabetic rats treated with different doses of 17b- oestradiol or progesterone
4. Edwina H Yeung,Cuilinzhang, Sunni L Mumford- Longitudinal study of insulin resistance and sex hormones over the menstrual cycle: the biocycle study. J Clini Endocrinol metab. Dec 2010; 95(12) 5435-5442
5. T.S Gugapriya, S Karthick, and B. Nagarjuna – A Prospective study of variability in glycemic control during different phases of the menstrual cycle in type 2 diabetic women using high sensitivity C - reactive protein. J Clin Diagn Res. Apr 2014; 8(4): cc01-cc04.
6. Christopher A, Newton M D, Philip Raskin M D. Diabetic Ketoacidosis in type 1 and type 2 Diabetes mellitus– clinical and biochemical differences. JAMA Internal Medicine Sep 2004, vol 164, no .17.
How to Cite
1.
Suvarna P, Shabbir P M. PROGESTERONE INDUCED DIABETIC KETOACIDOSIS IN A YOUNG FEMALE: A CASE REPORT. Med. res. chronicles [Internet]. 2015Jan.15 [cited 2024May3];2(1):23-5. Available from: https://medrech.com/index.php/medrech/article/view/44
Section
Case Report