Role and effects of n-acetylcysteine in rat killer (rodenticide) poisoning

  • J. Chandravanshi Assistant Professor, Department of Medicine, Chhattisgarh Institute of Medical Science (CIMS) , Bilaspur , Chhattisgarh, India
  • A. Kori Assistant Professor, Department of Medicine, Chhattisgarh institute of Medical Science (CIMS) , Bilaspur Chhattisgarh, India
  • P. Tembhurnikar Professor and head of the Department, Department of medicine (CIMS) Bilaspur, Chhattisgarh, India
  • A. Thakur Associate Professor Department of Medicine, (CIMS ) Bilaspur , Chhattisgar, India.
Keywords: N-acetylcysteine, Liver impairment, Rodenticide poisoning


Introduction:- Rodenticide is one of the pesticides and heterogeneous substances used to kill rats. Rodenticide poisoning is a major health problem in Asian countries, particularly the mode of self-poisoning, prevalent in India. It causes hepatotoxicity and no antidote has been found. N-acetylcysteine (NAC) is a powerful antioxidant and used in the treatment of acetaminophen-induced hepatotoxicity. The main objectives of this study were to determine the role of NAC in liver impairment rodenticide poisoning patients.

Methods:- Patients who ingested rat killer poison and age >15 years were included in the study. Patients having jaundice, liver disease, and age <15 years were excluded from the study.

Results:- Out of 50 patients. 27 (54%) were females and 23 (46%) were males. Age group between 21-30 years contributes the highest 20 (40%). The majority of types of rodenticide compounds consumed by patients were pasted 29 (58%) and less than four hours 26 (52%) patients were admitted. and 7 (14%) patients died.

Conclusion:-In liver impairment rodenticide poisoning patients, early use of NAC shows a significant result and the rate of recovery is also high. N-acetylcysteine, Rodenticide poisoning, Liver impairment. 


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DOI: 10.26838/MEDRECH.2021.8.1.472
Published: 2021-01-15
How to Cite
Chandravanshi J, Kori A, Tembhurnikar P, Thakur A. Role and effects of n-acetylcysteine in rat killer (rodenticide) poisoning . Med. res. chronicles [Internet]. 2021Jan.15 [cited 2021Apr.20];8(1):13-8. Available from:
Original Research Article