Etiological Profile Of Viral Hepatitis In North India: A Cross Sectional Study
Introduction: Viral hepatitis continues to remain an important public health concern, particularly in developing nations like India. Majority of such cases present with a mild anicteric illness in children. Severe illness, including progression to acute liver failure, is also known to occur.
Objective: To study the seroprevalence of markers of viral hepatitis in children less than 5 years, who present with jaundice.
Materials and methods: We performed a cross-sectional study on 397 children less than 5 years of age who presented with jaundice to the hospital. The study population was screened for serological markers of the hepatotropic viruses. A structured questionnaire was drafted to enquire about the immunization status and source of potable water. Statistical analysis used: Statistical analysis was performed using the Epi Info software 3.5.4 version 2012.
Results: Our study showed that Hepatitis A was the commonest cause of acute viral hepatitis in children less than 5 years of age, followed by Hepatitis E virus. Hepatitis A and E co-infection was the most common type of co-infection. Conclusion: The efficacy of vaccination against Hepatitis A and B has been reiterated in our study. Using any method of water filtration protects against Hepatitis A and E infection.
Irshad M, Singh S, Ansari MA, Joshi YK. Viral Hepatitis in India. A report from Delhi. Glob J Health Sci2010;2;96-103.
Kaur R, Gur R, Berry N, Kar P. Etiology of endemic viral hepatitis in urban North India. Southeast Asian J trop Med Public Health 2002;33;845-8.
Poddar U, Thapa BR, Prasad A, SinghK. Changing spectrum of sporadic acute viral hepatitis in Indian children. J Trop Pediatrics2002;48: 210-3.
Kumar S, Ratho RK, Chawla YK, Chakraborti A. The incidence of sporadic viral hepatitis in North India: A preliminary study. Hepatobiliary Pancreat Dis Int2007;6: 596-9 .
Gupta S, Jain P, Prakash S, Singh KP. Prevalence of hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E virus as cause of acute viral hepatitis in
North India: A hospital based study. Indian journal of Medical Microbiology, 2013;3:261-265.
VermaY, Rajput S, Rajput N. Seroprevalence of Hepatitis A Virus Infection in Children. Sch. J. App. Med. Sci., 2014; 2(3D):1144-1147
Arankalle VA, Sarada Devi KL, Lole KS, Shenoy KT, Verma V, Haneephabi M. Molecular characterization of hepatitis A virus from a large outbreak from kerala, India. Indian J Med Res 2006;123: 760-9.
Kumar S, Ratho RK, Chawla YK, Chakraborti A. The incidence of sporadic viral hepatitis in North India: a preliminary study. Hepatobiliary Pancreat Dis Int2007; 6: 596-9.
Chandra N S, Sharma A, Rai R R& Malhotra B. Contribution of hepatitis E virus in acute sporadic hepatitis in north western India. Indian J Med Res 2012;136: 477-482.
Qamer S, Shahab T, Alam S, Malik A, Afzal K. Age- specific prevalence of hepatitis B surface antigen in pediatric population of Aligarh, North India. Indian J Pediatr2004;71: 965-967.
Chakravarthi A, Rawat D, Jain M. A study on the perinatal transmission of the hepatitis B virus. Indian J Med Microbiol2005;23: 128-130.
Gupta N, Kumar V, Kaur A. Seroprevalence of HIV, HBV, HCV and syphilis in voluntary blood donors. Indian J Med Sci; 58: 255-257.
Sonwane BR, Birare SD, Kulkarni PV. Prevalence of seroreactivity among blood donors in rural population. Indian J Med Sci;57: 405-407.
Mohana T, Vaithilingam A, Franklin A, Reddy EP. The prevalence of serological markers of viruses causing acute hepatitis in south Indian population. Int J Biol Med Res. 2011; 2: 925-928.