A review on the use of corticosteroids
corticosteroids [CS] are used to treat various diseased conditions such as inflammatory diseases including allergic diseases and hypersensitivity reactions. Cortisol is produced in the adrenal gland and a variety of other hormones are produced through cholesterol metabolism. They are elaborated in the regulation of different processes such as metabolism electrolyte regulation inflammation, and stress responses based on their major effects. Corticosteroids acts as anti-inflammatory, antiproliferative, immunosuppressive and shows vasoconstrictive effects. Prolonged use of corticosteroid leads to hormonal changes within the body which may cause a wide range of side effects. Once corticosteroids are prescribed the patient should be monitored regularly and reviewed to assess the response to the treatment with adjusting the dose at a minimum. When corticosteroids are used thoroughly as intensive therapy or for prolonged courses, a tapering strategy is recommended to prevent signs and symptoms of adrenal insufficiency due to hypothalamic-pituitary-adrenal axis suppression.
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