Study of clinical, radiological, and histopathological features of bone lesions- A two-year study

  • Dr Vivek Kharolkar Assistant Professor, Department of Pathology, Grant Government Medical College, Mumbai, Maharashtra, India.
  • Dr Naveen Chawla
  • Dr Pratik Chide Assistant Professor, Department of Pathology, Grant Government Medical College, Mumbai, Maharashtra, India
  • Dr Megha Kinake Assistant Professor, Department of Pathology, Grant Government Medical College, Mumbai, Maharashtra, India
Keywords: Bone lesion, Radiology, Biopsy, Malignant, Benign, Osteochondroma, Osteomyelitis, Histopathology

Abstract

Background: A pathological bone lesion can present in any form of inflammatory to neoplastic conditions and they pose a definite diagnostic challenge. The aim of the present research was to study the incidence, age of presentation, and site of bone lesions, overview the clinical, imaging, and pathologic findings, and also compare radiological and histological findings.  Methods: This study was conducted in 30 cases of bone lesions, who presented to a tertiary care hospital from May 2010 to September 2012. Clinical examination was done initially, followed by radiological imaging (X-ray, CT & MRI). Based on imaging, the decision of biopsy was taken for final diagnosis. Histopathological examination was done on Hematoxylin and Eosin stained slides. Results: Out of 30 cases, 14(46.66%) cases were benign, 14(46.66%) were malignant tumors and 2(6.66%) were non-neoplastic lesions. Osteochondroma (35.71%) was the most common benign bone tumor and multiple myeloma (28.57%) was the commonest malignant tumor while non-neoplastic lesions were avascular necrosis of hip & chronic osteomyelitis. The primary bone tumors occurred mostly in 0-50 years, while half cases of multiple myeloma and metastatic tumors were seen 1-2 decades higher. 85.71% of benign tumors occurred in males while malignant tumors showed equal sex incidence. All non-neoplastic cases occurred in males. The femur was most commonly involved long bone while the pelvis was the most commonly involved flat bone. Radiological diagnosis was consistent with histopathological diagnosis in 80% of cases. Conclusion: Age, sex, and site are important clinical parameters. Radiology and imaging investigation is an essential step in the diagnosis, prior to histopathological study. Clinical, imaging and histopathology thus remains the key for diagnosing bone lesions; especially so in bone tumors.

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References

Mohammed A, Sani MA, Hezekiah IA, Enoch AA. Primary bone tumors and Tumor-like lesions in children in Zaria, Nigeria. Afr J Paediatr Surg.2010;7:16–8.

Patel D, Patel P, Gandhi T, Patel N, Patwa J. Clinicopathological study of bone lesions in tertiary care center – A review of 80 cases. IJAR 2015;3:1267-72.

Jain K, Sunila, Ravishankar R, Mruthyunjaya, Rupakumar CS, Gadiyar HB, et al. Bone tumors in a tertiary care hospital of South India: A review 117 cases. Indian J Med Paediatr Oncol 2011;32:82-5.

Yeole BB, Jussawala JD. Descriptive epidemiology of bone cancer in Greater Bombay. Indian Journal of Cancer.1998; 35: 101-106.

Kethireddy S, Raghu K, Chandra Sekhar KPA, Babu YS, Dash M. Histopathological evaluation of neoplastic and non-neoplastic bone tumours in a teaching hospital. J Evol Med Dent Sci 2016;5:6371-4.

Hathila RN, Mehta JR, Jha BM, Saini PK, Dudhat RB, Shah MB. Analysis of bone lesions in tertiary care center – A review of 79 cases. Int J Med Sci Public Health 2013;2:1037-40.

Deoghare SB, Prabhu MH, Ali SS, Inamdar SS. Histomorphological spectrum of bone lesions at tertiary care centre. Int J Life Sci Res 2017;3:980-5.

Modi D, Rathod GB, Delwadia KN, Goswami HM. Histopathological study of bone lesions – A review of 102 cases. IAIM 2016;3:27-36.

Cohen J. A coefficient of agreement for nominal scales. Educational and Psychological Measurement. 1960; 20:37-46.

Mohammed A, Isa HA. Pattern of primary tumors and tumor-like lesions of bone in Zaria, Northern Nigeria: A review of 127 cases. West African Journal Of medicine 2007:26(1):37-41.

Kumavat PV, Gadgil NM, Chaudhari CS, Rathod UK, Kshirsagar GR and Margam SS.Bone Tumors and Tumor-like lesions: A study in A Tertiary Care Hospital, Mumbai. Annals of Pathology and Laboratory Medicine 2017;4(1):A11 –A18.

Bamanikar SA, Pagaro PM, Kaur P, Chandanwale SS, Bamanikar A, Buch AC. Histopathological study of primary bone tumours and tumour-like lesions in a medical teaching hospital. JKIMSU 2015; 4(2): 46-55.

Jain K. et al. Bone tumors in a tertiary care hospital of south India: Areview of 117 cases. Indian J Med Paediati Oncol. Apr- Jun 2011; 32(2):82-85.

Baena- Ocampo LC, Ramirez-Perez E, Linares-Gonzalez LM, Delgado-Chavez R. Epidemiology of bone tumors in Mexico city: retrospective clinicopathologic study of 566 patients at a referral institution. Annals of Diagnostic Pathology. 2009; 13: 16-21.

Kokode D. A clinicopathological study of lesions of bone. Clinical and diagnostic pathology, 2019; 3:1-5.

Deoghare SB, Prabhu MH, Ali SS, Inamdar SS: Histomorphological Spectrum of Bone Lesions at Tertiary Care Centre. Int. J. Life. Sci. Scienti. Res., 2017; 3(3): 980-985.

Fletcher CD, Unni KK, Mertens F, editors. Lyon: ARC Press; 2002. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Soft Tissue and Bone. IARC Press. Lyon; 2002. p.228.

Inwards KY, Unni KK. Bone tumors. In. Mills. Stacey E. editors. Sternberg’s diagnostic Surgical Pathology. 5th edition. Lippincott Williams and Wilkins; 2010:261-262.

WolfangDahnert. Musculoskeletal system. Radiology Review manual .6th ed. Lippincott Williams and Wilkins; 2007. p.56.

Kaplan I., Calderon S., Buchner A. Peripheral osteoma of the mandible- A study of ten new cases and analysis of the literature. J. Oral. Maxillofac. Surg. 1994; 52(5) : 467-70.

Thomas H. Berquist. Mark J Kransdorf. Muskuloskeletal Neoplasms Ch10 In. Thomas H. Berquist. Editor. Muskuloskeletal Imaging companion, 2nd edition Lippincott Williams and Wilkins; 2007.p. 675.

Rosai J. Editor. Rosai and Ackerman’s Surgical Pathology. 9th edition Mosby Elsevier; 2004:2164-2165.

Bertoni F, Bacchini P, Hogendoorn PCW. Chondrosarcoma. In: Fletcher CDM, Unni KK, Mertens F. (Edi). World Health Organization Classification of Tumours. Pathology and Genetics.Tumours of Soft Tissue and Bone. IARC Press. Lyon, France. 2002: 234 –257.

Rosai J. Editor. Rosai and Ackerman’s Surgical Pathology. 9th edition Mosby Elsevier; 2004. p.2140-2142,2188-94.

Negash BE, Admasle D, Wamisho BL, Tinsay MW. Bone tumors at Adidas Ababa University, Ethopia: Agreement between radiological and histopathological diagnoses, a 5-year analysis at Black-Lion Teaching Hospital. International Journal of Medicine and Medical science. 2009; 1(4): 119-125.

CITATION
DOI: 10.26838/MEDRECH.2020.8.5.558
Published: 2021-10-10
How to Cite
1.
Kharolkar V, Chawla N, Chide P, Kinake M. Study of clinical, radiological, and histopathological features of bone lesions- A two-year study. Med. res. chronicles [Internet]. 2021Oct.10 [cited 2021Oct.21];8(5):409-20. Available from: https://medrech.com/index.php/medrech/article/view/531
Section
Original Research Article