Fibrinogen levels amongst patients suffering from vasculopathy- IHD/Stroke/DVT: A novel risk factor
Abstract
Recently, research is underway and many other factors are being identified to mention Fibrinogen (Fi) as a likely novel risk factor for vasculopathies. It is Likely that with higher fibrinogen levels in the blood, local deposition of fibrin may be more pronounced and fibrinolysis poorer so it helps in thrombosis. Hence, this study was undertaken to study the prevalence of new risk factor (Fibrinogen) in the general population (both young and old) and also to find out the difference in prevalence rates (if any) in the young (less than 45 years of age) and in the elderly (more than 45 years of age).
This was the case-control study done in the cardiology unit of Bharti Hospital, Pune. All the patients diagnosed as cases of vasculopathies especially IHD/ Stroke/ DVT (n=75) were enrolled as cases for the study and Healthy volunteers of the same age and gender-matched (n=75) were enrolled as the controls and subjected to the following inclusion and exclusion criteria. All cases and controls were assessed for their fibrinogen level at day 0 of the admission by using a Fibrinogen testing kit. The mean fibrinogen level of 357.5867 mg/dl (36.5218) in vasculopathy cases whereas 310.2800 mg/dl (27.6100) in controls with a statistically significant p-value by unpaired ‘t’ and Mann- Whitney statistics.62% Cases had Fibrinogen level above 350mg/dl in comparison only 10% controls had levels above 350mg/dl. On comparing fibrinogen individual vasculopathy, it was found that fibrinogen was a more significant risk factor in stroke >DVT> IHD.
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