Unrecognized renal dysfunction in patients with acute stroke- Cross sectional study
Background and Objectives: Unrecognized renal insufficiency, defined as an estimated glomerular filtration rate <60 mL/min/l .73 m2 in the presence of normal serum creatinine levels, is a common comorbid condition among patients with various cardiovascular conditions. The current study was aimed to evaluate the prevalence and clinical significance of unrecognized renal dysfunction in patients admitted with acute stroke.
Patients & Methods: This cross sectional study consisted of patients with acute stroke admitted in medical ward at Stanley medical college. Estimated glomerular filtration is estimated using MDRD and CKD — EPI formula. Study group is divided into three groups (Normal renal function, Unrecognized and Recognized renal dysfunction) as per eGFR. The two primary outcomes such as severe disability at hospital discharge and in-hospital mortality are compared in each group.
Results: Of the 100 patients with stroke included in the study, 62% had a normal renal function, 31% had recognized renal insufficiency, and 7% had unrecognized renal insufficiency. Mortality rates are higher in patients with recognized and unrecognized renal insufficiency compared with patients with normal renal function (29% and 28.5% and 9.6%) respectively, P <0.04053). Similarly, severe disability rates at discharge are also higher in patients with recognized and unrecognized renal insufficiency compared with patients with normal renal function (72.27%, 80 %, and 32.14%) respectively.
Conclusion: Unrecognized renal insufficiency is common among patients with acute stroke and is associated with adverse short-term outcomes.
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