New perspective with Gliclazide MR on screening and management of MODY patients in India

  • Dr. Prabir Kumar Biswas MBBS, MD (General Physician), P-19 Raipur Road, Flat No-B2, Kolkata -700084
  • Dr. Subhasis Pramanik Khirki Bagan Lane, Ward 3 Ranaghat, West Bengal Pin 741201
  • Dr. Rajesh Kumar Kewat MBBS, MD (General Medicine), Marble City Hospital and Research Center, Napier Town Jabalpur, Madhya Pradesh 482001
  • Dr. R. M. Mundada Consultant Physician, Ramraksha Hospital, Block No.- 602/1204 Manera Road, Ulhasnagar - IV, Ulhasnagar, Maharashtra 421004
  • Dr. Samiran Samui MD (General Medicine), Manikat Arambagh, Hooghly, Burdhwan 712617
Keywords: Gliclazide MR, MODY Patients, India, Diabetes

Abstract

Maturity-onset diabetes of the young (MODY) is a genetically heterogeneous group of monogenic endocrine disorders characterized by autosomal dominant inheritance and pancreatic β-cell dysfunction. Currently, 14 MODY subtypes have been identified, with differences in incidence, clinical features, diabetes severity and related complications, and treatment response. This type of diabetes is mostly misdiagnosed as either type 1 or type 2 diabetes mellitus because it is difficult to differentiate between these forms of diabetes due to clinical similarities, the high cost of genetic testing, and lack of awareness. The correct diagnosis for individuals with MODY is of utmost importance, as the applied treatment depends on the gene mutation or is subtype-specific. Sulphonylureas, specifically Gliclazide, has emerged as the drug of choice for MODY patients. This review will discuss the importance of screening in MODY patients and its management and the status of MODY patients in India.

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References

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CITATION
DOI: 10.26838/MEDRECH.2022.9.2.590
Published: 2022-04-09
How to Cite
1.
Biswas PK, Pramanik S, Kewat RK, Mundada RM, Samui S. New perspective with Gliclazide MR on screening and management of MODY patients in India. Med. res. chronicles [Internet]. 2022Apr.9 [cited 2024Mar.28];9(2):116-20. Available from: https://medrech.com/index.php/medrech/article/view/571
Section
Original Research Article