Clinical profile and outcome of patients with diabetic foot infection: A single centre study

  • Dr. Anirudha Sardar Resident Surgeon, Department of Surgery, Khulna Medical College Hospital, Khulna, Bangladesh
  • Dr. Asadullahil Galib Assistant Professor, Department of Surgery, Khulna Medical College Hospital, Khulna, Bangladesh
  • Dr. Polash Kumar Dey Junior Consultant, Department of Surgery, Khulna Medical College Hospital, Khulna, Bangladesh.
  • Dr. A. K. M. Lutful Haque Medical Officer, Kurmitola General Hospital, Dhaka, Bangladesh.
  • Dr. Md. Mahmudul Hasan Junior consultant (surgery), OSD DG Health, Deputed attached in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
Keywords: clinical profile, outcomes, diabetic foot infections (DFI).

Abstract

Introduction: Diabetes mellitus with its limb and life-threatening complication such as diabetic foot infection and amputation are increasing at epidemic rates all over the world.

Aim of the study: The study aims to find out the clinical profile and outcomes of patients with diabetic foot infections (DFI).

Methods: This was a prospective study conducted at a tertiary care institute. A total of 82 patients were included and analyzed in this study from January 2020 to December 2022. This study recruited patients >18 years of age, with DFI. All patients underwent a detailed history and clinical examination. Patients were classified as per the International Working Group on the Diabetic Foot -IDSA classification. The patients were followed up every month for 3 months. Clinical outcome was studied regarding the rate of amputations, readmissions, and mortality.

Result: A total of 82 patients were included and analyzed in this study. There are 36 (43.90%) patients from the age range 55-65 which is height and the lowest is 2(2.44%) patients from the age range 15-24. The ulcer healing during follow-up of the study, the mean±SD of the baseline is 14.85±23.12. After 1 month the percentage of wound healing is 20.88% and the mean±SD is 11.75±22.68, after 2 months the percentage of wound healing is 43.16% and the mean±SD is 8.44±22.05 and after 3 months the percentage of wound healing is 57.04% and the mean±SD is 6.38±21.19. The p-value of follow-up duration is equal to <0.001 which was shown as a significant change.

Conclusion: This study shows the predominance of monomicrobial growth and Gram-negative organisms in diabetic foot patients. With the increase in the severity of DFI, there was an increased rate of hospital readmissions, amputations (major and minor), and mortality. Dimensions of the ulcer may have a bearing on the rate of minor amputations.

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References

van Dieren S, Beulens JWJ, van der Schouw YT, et al. The global burden of diabetes and its complications: an emerging pandemic. Eur J Cardiovasc Prev Rehabil. 2010;17(Suppl. 1): S3–S8. DOI:10.1097/01. hjr.0000368191.86614.5a

Reiber GE. Epidemiology of foot ulcers and amputation in the diabetic foot. In: Bowker J, Pfeifer M, editors. The diabetic foot. St. Louis: Mosby; 2001. p. 12–32.

Adam DJ, Raptis S, Fitridge RA. Trends in the presentation and surgical management of the acute diabetic foot. Eur J Vasc Endovasc Surg. 2006; 31:151– 156. DOI: 10.1016/j.ejvs.2005.05.039

El-Maadawy G, Sabry A, Mohi Elden H, et al. Different procedures in the management of diabetic foot infections. Trends Med Res. 2010; 5:16–30. DOI:10.3923/tmr.2010.16.30

Waspadji S. Kaki diabetik: kaitannya dengan neuropati diabetik. In: Djokomoeljanto R, Darmono Suhartono T, editors. Kaki diabetik: patogenesis dan penatalaksanaan. Semarang: Diponegoro University Press; 1996. p. E1–E23.

Decroli E, Karimi J, Manaf A, et al. Profil ulkus diabetik pada penderita rawat inap di bagian penyakit dalam RSUP Dr. M. Djamil Padang. Maj Kedokt Indones. 2008; 58:3–7.

Yusuf S, Okuwa M, Irwan M, et al. Prevalence and risk factor of diabetic foot ulcers in a regional hospital, eastern Indonesia. Open J Nurs. 2016; 6:1–10. DOI:10.4236/ojn.2016.61001.

Diabetes and research in Europa: The Saint Vincent declaration. Diabetic Med., 1990, 7, 360

The International Working Group on the Diabetic Foot: International Consensus on the Diabetic Foot. Amsterdam; 1999. International Working Group on the Diabetic Foot: International Consensus on the Diabetic Foot

Sims S.D., Cavanagh R.P., Ulbrecht S.J., Risk factors in the infected diabetic foot. Recognition and management, Physical Therapy., 1988, 68 (12), 1887- 1903

Armstrong D.G., Lavery L.A., Van Houtum W.H., Seasonal variations in lower extremity amputation, J. Foot Ankle Surg., 1997, 36, 146-150.

Bakker K, Apelqvist J, Lipsky BA, Van Netten JJ. International Working Group on the Diabetic Foot. The 2015 IWGDF guidance documents on prevention and management of foot problems in diabetes: Development of an evidence-based global consensus. Diabetes Metab Res Rev. 2016;32(Suppl 1):2–6.

Gadepalli R, Dhawan B, Sreenivas V, Kapil A, Ammini AC, Chaudhry R, et al. Aclinico-microbiological study of diabetic foot ulcers in an Indian tertiary care hospital. Diabetes Care. 2006; 29:1727–32.

Ramakant P, Verma AK, Misra R, Prasad KN, Chand G, Mishra A, et al. Changing microbiological profile of pathogenic bacteria in diabetic foot infections: Time for a rethink on which empirical therapy to choose? Diabetologia. 2011; 54:58–64.

Yakaryılmaz FD, Öztürk ZA. Treatment of type 2 diabetes mellitus in the elderly. World J Diabetes. 2017; 8:278–85.

Reinehr T. Type 2 diabetes mellitus in children and adolescents. World J Diabetes. 2013; 4:270–81.

Fonseca VA. Defining and characterizing the progression of type 2 diabetes. Diabetes Care. 2009;32 (Suppl 2): S151–6.

Ramakant P, Verma AK, Misra R, Prasad KN, Chand G, Mishra A, et al. Changing microbiological profile of pathogenic bacteria in diabetic foot infections: Time for a rethink on which empirical therapy to choose? Diabetologia. 2011; 54:58–64.

Bansal E, Garg A, Bhatia S, Attri AK, Chander J. Spectrum of microbial flora in diabetic foot ulcers. Indian J Pathol Microbiol. 2008; 51:204–8.

Tiwari S, Pratyush DD, Dwivedi A, Gupta SK, Rai M, Singh SK, et al. Microbiological and clinical characteristics of diabetic foot infections in Northern India. J Infect Dev Ctries. 2012; 6:329–32.

Dinh T, Veves A. The influence of gender as a risk factor in diabetic foot ulceration. Wounds. 2008; 20:127–31.

Christman AL, Selvin E, Margolis DJ, Lazarus GS, Garza LA. Hemoglobin A1c predicts the healing rate in diabetic wounds. J Invest Dermatol. 2011; 131:2121–7.

Williams DT, Price P, Harding KG. Review: The clinical evaluation of lower limb perfusion in diabetic foot disease. Br J Diabetes Vascul Dis. 2003; 3:394–8.

Jog AS, Shadija PG, Ghosh SJ. Detection of multidrug-resistant gram-negative Bacilli in type II diabetic foot infections. Int J Med Health Sci. 2013; 2:186–94.

Potier L, Abi Khalil C, Mohammedi K, Roussel R. Use and utility of ankle-brachial index in patients with diabetes. Eur J Vasc Endovasc Surg. 2011; 41:110–6.

Rastogi A, Sukumar S, Hajela A, Mukherjee S, Dutta P, Bhadada SK, et al. The microbiology of diabetic foot infections in patients recently treated with antibiotic therapy: A prospective study from India. J Diabetes Complications. 2017; 31:407–12.

Potier L, Abi Khalil C, Mohammedi K, Roussel R. Use and utility of ankle-brachial index in patients with diabetes. Eur J Vasc Endovasc Surg. 2011; 41:110–6.

Lavery LA, Armstrong DG, Murdoch DP, Peters EJ, Lipsky BA. Validation of the infectious diseases society of America's diabetic foot infection classification system. Clin Infect Dis. 2007; 44:562–5.

Wukich DK, Hobizal KB, Brooks MM. The severity of diabetic foot infection and rate of limb salvage. Foot Ankle Int. 2013; 34:351–8.

CITATION
DOI: 10.26838/MEDRECH.2022.9.3.601
Published: 2022-06-24
How to Cite
1.
Sardar A, Galib A, Dey PK, Haque AKML, Hasan MM. Clinical profile and outcome of patients with diabetic foot infection: A single centre study. Med. res. chronicles [Internet]. 2022Jun.24 [cited 2024Dec.22];9(3):191-9. Available from: https://medrech.com/index.php/medrech/article/view/583
Section
Original Research Article