Efficacy of Ibuprofen and Paracetamol in the management of hemodynamically significant patent ductus arteriosus in preterm babies.
Abstract
Background: Preterm babies are at high risk for many complications and multiple morbidities. A patent ductus arteriosus (PDA) is one of the major problem which causes significant alteration in hemodynamics. There are various modalities of closing hemodynamically significant PDA such as surgical ligation and closure by various pharmacological agents like Indomethacin, Ibuprofen and Paracetamol. The present study was performed to explore the use of oral Indomethacin, Ibuprofen and Paracetamol in preterm babies in a rural based tertiary care center which has its own limitations.
Aims & Objectives: To compare the efficacy, side-effects and outcome of Ibuprofen and Paracetamol in the management of hemodynamically significant Patent Ductus Arteriosus in preterm babies.
Material and Methods: All neonates admitted at Pravara Rural Hospital during December 2020 to April 2022 with birth weight < 1800 grams were included in our study. All babies fulfilling the inclusion criteria were given either oral ibuprofen or paracetamol and result to each of these along with side effects was monitored for.
Results: PDA closure rate was maximal with oral paracetamol though the difference in closure rate of these drugs was statistically not significant. Preterm with gestational age lesser than 32 weeks showed better results with oral ibuprofen. Preterm with gestational age more than 32 weeks showed better closure rates with oral paracetamol.
Conclusion: This study demonstrates that Patent Ductus Arteriosus closure in preterm babies can be attempted with oral use of any of these drugs i.e Ibuprofen and Paracetamol. In our study, maximal success was obtained with use of oral paracetamol though the difference in closure rate of both drugs was statistically not significant.
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References
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