Profile of infections in nephrotic syndrome patients of western rural Maharashtra.
Abstract
Background: Infection is a major complication in children with Nephrotic syndrome. Patients with relapse will have increased susceptibility to bacterial infection because of urinary losses of immunoglobulins & properdin factor B, defective cell-mediated immunity, immunosuppressive therapy, malnutrition & edema, or ascites acting as potential culture medium.
Aims & Objectives: To study the spectrum of infections in nephrotic syndrome of childhood.
Material and Methods: A longitudinal observational study was conducted including the nephrotic syndrome cases after ethical approval from the institution at a tertiary care hospital from November 2020 to October 2021.
Results: The sex ratio of the study was 1.44:1 with a mean age of 4.2 years. The most common presenting feature in our study was decreased urine output with generalized edema and the most common type of infection was upper respiratory tract infections. Our study found that most common organism causing infection in NS was Escherichia coli (E. coli).
Conclusion: With high index of suspicion, early institution of appropriate antibiotics, aggressive management of infections together with use of steroids enables remission of NS and support better prognosis.
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