Relation of serum prolactin level to systemic lupus erythematosus disease
Abstract
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple organ systems. Prolactin accelerates the breakdown of immune tolerance by promoting the survival, maturation and activation of autoreactive B and T cells, dendritic cells and macrophages and may play a role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus. Premature cardiovascular disease is the leading cause of morbidity in lupus which may be directly associated with altered lipid metabolism in systemic lupus erythematosus patient.
Objective: To find out the relation of serum prolactin and lipid profile with systemic lupus erythematosus patients.
Methodology: This cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from January 2017 to December 2017. In this study, fifty diagnosed patients of SLE (Group A) and fifty apparently healthy individuals (Group B) of both sexes were selected according to the selection criteria from Department of Medicine, Dhaka medical college hospital, Dhaka (Group A) and by personal contact (Group B). Baseline parameters (body mass index, blood pressure and fasting plasma glucose) of both groups were measured. Serum prolactin was estimated by enzyme immune assay.
Results: Out of 100 patients included in our study. Mean ± SD of serum prolactin level was significantly higher (p <0.001) in SLE patients (37.95 ± 18.47) ng/ml when compared to healthy controls (14.82 ± 2.86) ng/ml. Distribution of serum prolactin status in SLE patients shows among 50 patients 37 (74%) has hyperprolactinemia and 13 patients have normal prolactin level. Among age (mean ± SD), gender distribution and duration of disease of study subjects among groups. There were no significant differences in terms of age and gender between SLE patients and healthy subjects show homogenecity of both groups. Shows serum prolactin of the study subjects in both groups. Serum prolactin level was significantly higher in SLE patients than healthy individual. Serum prolactin showed significant positive correlation with SLE (p<0.001). In Group A thirty seven SLE patients had raised serum prolactin & thirteen had normal prolactin level. The correlation of serum prolactin with SLE. There was significant positive correlation of serum prolactin.
Conclusion: From present study it can be concluded that systemic lupus erythematosus is related to increased serum prolactin level and with dyslipidemia.
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References
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