Progression & prognosis of Covid-19 patients having diabetes mellitus
Background: Diabetes patients experience a variety of internal health issues, including immune deficiencies, inflammatory storms, hyperglycemia, coagulation risks, and elevated levels of ACE2 receptors. They also suffer from various illnesses like high blood pressure, cardiovascular disease, kidney problems, visual issues, and a host of others. None of these factors raise the chance of contracting SARS-CoV-2. However, once they are infected, the condition worsens to the point that the death rate is high.
Objective: This study aimed to examine the severity of symptoms between COVID-19 participants with and without diabetes.
Methods: A total of 347 patients with confirmed SARS CoV-2 were selected by a purposive sampling method for this retrospective, single-center study that took place from June 1, 2020, to August 31, 2020, at the Department of Medicine, TMSS Medical College, and Rafatullah Community Hospital, Bogura, Bangladesh. We investigated and compared their sociodemographic information, clinical traits, morbidities, lab results, and CT scan results. The study was approved by the ethical committee of the mentioned hospital. All of the patients tested positive for COVID 19. Patients with a COVID 19 negative result and those younger than 18 years old were, however, eliminated based on the study's exclusion criteria.
Results: Diabetes patients experienced worse hospital outcomes, including a death rate of 19.4% (p=0.002163), and longer hospital stays (p = 0.0001) compared to non-diabetic patients. Additionally, diabetic patients got more oxygen therapy (32 hours, p 0.05), injectable antiviral drugs (161, p 0.05), and low molecular weight heparin (105, p 0.05) than non-diabetics. These findings suggest that diabetes affects the prognosis of COVID 19.
Conclusion: Diabetes worsens the prognosis and is a risk factor for the Covid-19 symptoms' quick progression. Therefore, individuals with Covid-19 infection and diabetes should receive additional attention because they could deteriorate at any time.
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