Efficacy Of Helicobacter Pylori Eradication In Helicobacter Pylori Positive Functional Dyspepsia Patients-A Double-Blind, Randomized, Placebo-Controlled Trial
Multiple etiopathogenesis have been proposed for functional dyspepsia. But no conclusive mechanisms have been established yet. Many studies reported that H. pylori produce dyspeptic symptoms without any macroscopic lesion in the gastroduodenal mucosa. Some studies also reported that eradication of H. pylori relieves the symptoms of functional dyspepsia. The main objective of this double blind randomized placebo controlled clinical trial was to see the response of H. pylori eradication in the management of ‘H. pylori positive functional dyspepsia’. We conducted the study on H. pylori positive functional dyspepsia patients visiting the gastroenterology OPD and see the effects of H. pylori eradication on their symptom resolution. Consecutive 59 H. pylori positive functional dyspepsia patients were randomly assigned to receive either Anti H. pylori therapy (Levofoxacin, Amoxicillin and Omeprazole) or placebo for 14 days. H. pylori status was assessed by 13C urea breath test for inclusion into the study and 2 months later for eradication status along with symptom resolution. 23 patients receiving Anti H. pylori therapy and 17 receiving placebo were available for analysis. Two months after completion of therapy 56.5% patients resolved their symptoms who received Anti H. pylori therapy. On the other hand, 47.1% patients who received placebo relieved their dyspeptic symptoms. Dyspeptic symptom resolution was also not statistically significant when comparison made between H. pylori eradicated and non- eradicated subjects irrespective of their treatment regimen (p=0.102). So in this study we found that there is no relationship between H.pylori eradication and resolution of dyspeptic symptoms in patients with functional dyspepsia.
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