Prevalence of LV diastolic dysfunction in people with type 2 diabetes mellitus with a normal systolic function
Abstract
Background and Aims: To determine the incidence of LV diastolic dysfunction (LVDD) in type 2 diabetics having a normal LV systolic function. This observational study aimed to determine the prevalence of LVDD in a normotensive T2DM population with a preserved Left Ventricular Ejection Fraction (LVEF) and to impress the importance of initiating early therapy with agents like SGLT2 inhibitors.
Materials and Methods: Persons diagnosed with T2DM underwent standard TTE and assessment of their LVEF and grading of LV diastolic dysfunction. LVEF ≥ 50% was considered as normal. All the subjects underwent resting transthoracic 2-dimensional echocardiography and Doppler imaging, to assess left ventricular systolic and diastolic function. A total of 2,150 cases were assessed at the hospital, over 4 years.
Results: Of the 2,150 cases included 56% (1204) were males, and 44% (946) were females,
72% (1548), [59% males and 41% females] had Grade I LV diastolic dysfunction.
Conclusion: This observational study concludes that there is a huge prevalence of LV diastolic dysfunction, in people with T2DM, which is an important risk factor for cardiac morbidity and mortality, which may lead to the development of overt heart failure and progression to coronary artery disease if not corrected early.
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