Clinical profile and response to tuberculosis treatment in patients with chronic kidney disease
Abstract
Introduction: Tuberculosis (TB) is a major public health problem, especially in the developing countries Patients with CKD have a weakened immune system due to the chronic inflammatory state due to CKD per se, also due to long term renal replacement therapy. Aims of The Study
- To study the clinical profile of tuberculosis in chronic kidney disease patients
- To study the response to anti tubercular treatment including adverse effects.
Methodology: This study was carried out in the Department of Nephrology at Government Stanley Medical College and Hospital, Chennai during the period between October 2018-May 2019. A detailed history was taken, Age, symptomatology, non CKD risk factors like smoking, alcoholism, previous history of pulmonary TB, presence of diabetes mellitus, other infections like HCV, and in case of post-transplant patients, use of induction therapy, any graft dysfunction etc. was noted. The definitions for cure, treatment completed, and treatment failure being used in the study.
Results: There were a total of 55 patients with CKD diagnosed as tuberculosis by various means-clinical, histopathologic, biochemical, microbiologic, radiologic or a combination of factors.
Conclusion: Tuberculosis is a common infection among Chronic Kidney disease patients, due the immunosuppressed state, hence a high index of suspicion should be maintained, with ways of early screening to be followed based on clinical grounds. Risk factors, namely, smoking, alcoholism, diabetes mellitus predisposes CKD patients to Tuberculosis in addition to the immunosuppressed state of CKD.
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