Profile of Hepatic Dysfunction in Dengue Patients of Western Rural Maharashtra

  • Mohammed Arif doctor
  • Sandhya Dhambore
Keywords: Infection, Dengue, SGOT, SGPT


Background of the study: Dengue fever is benign syndrome caused by several arthropod-borne viruses. It is transmitted to human by bites of infected female Aedes mosquitoes . Levels of transaminase are raised; a higher increase in SGOT than SGPT suggests dengue rather than other virus infections.
Aim and objectives:To correlate the serum aminotransferase levels in patients with dengue infection with dengue serology, presenting to the pediatrics department of Pravara Rural Hospital, Loni.
Material and methods : This descriptive longitudinal hospital-based study was conducted from January 2022 to October 2022.
Results :A total of 100 patients were included in the study who were having dengue fever. The patients included were 1 to 12 years of age.Maximum number of patients were seen in the age group of 1-5 years.Included 64 males and 36 females, with male to female ratio was 1.7:1.
Conclusion: As this study and statistics points out that there is a significant association with biomarkers such as SGOT & SGPT; as that patients under careful supervision and management can able to prevent them from progressing to severe dengue. As early alterations of these biochemical markers can predict progressing to SEVERE DENGUE in patients with acute fever caused by dengue.


Download data is not yet available.


Scott B. Halstead. Dengue Fever,Dengue Hemorrhagic Fever,and Severe Dengue In: Kliegman R, Stanton B, St Geme JW, Schor NF, Behrman RE, editors. Nelson textbook of pediatrics. Edition 21. Philadelphia, PA: Elsevier Inc.; 2020. p. 1760.

Tanu Singhal,Rakesh Lodha,SK Kabra. Infections and Infestations: Vinod K,Arvind B,editor. Ghai essential Pediatrics.Edition 9th>elsevier.p 224-229

Dengue in India Indian J Med Res 136, September 2012, pp 373-390

Comprehensive guidelines for prevention and control of Dengue and

Dengue Haemorrhagic fever – WHO guidelines Revised and Expanded

Edition,Geneva 2009;1-144.

Infectious disease and Epidemiology theory and practice Nelson

Williams 2ndEdition

Mandell’s, Douglas and Bennett’s principle and practice of infectious

disease.7th edition.Vol.2

Piyush Gupta,Aashima Dabas.Dengue:Piyush Gupta,PSN Menon,Siddarth Ramji. PG Textbook of Pediatrics volume 2.Edition 3rd.Jaypee.p 1567-1577

Lauren McDanniel,MD. Blood Chemistry and Body Fluids:Harriet Lane,K.Kleinman,L. Mcdaniel editors. The Harriet Lane Handbook.Edittion 22nd.Elsevier.p 642

B Manohar, N Madhavi, B Sasikumar, Clinical profile and liver function in Dengue. NIJP 2015;4(1).

Dr. Siddappa F.D., Dr. Varsha Lakshman, & Dr. Madhu P.K. (2019). Prevalence of hepatic dysfunction in children with dengue fever. Pediatric Review: International Journal of Pediatric Research, 6(1), 8-16.

N., Yashwanth & Kumar, Rajendra & Rudrappa, Sudha. (2019). Liver function tests to predict the severity of dengue fever in serologically positive children below 18 years of age. International Journal of Contemporary Pediatrics. 6. 10.18203/2349-3291.ijcp20190069.

Chinna RS , Goyal O , Chihina DK, Goyal P, Kumar R, Puri S. Liver function tests in patients with dengue viral infection. Dengue Bulletin, 2008;32:110-117

Prakash O , Almas A , Jafri SMW, Hamid S, Akhtar J , Alishah H. Severity of acute hepatitis and its outcome in a patients with dengue fever in a tertiary care hospital Karachi , Pakistan (Southern Asia). BMC Gastroenterology, 2010; 10(43): 1-8.

Wong M , Shen E. The Utility of Liver Function Tests in Dengue. Annals Academy of Medicine, 2008; 37 (1): 82-83.

DOI: 10.26838/MEDRECH.2023.10.5.704
Published: 2024-01-19
How to Cite
Mohammed Arif, Sandhya Dhambore. Profile of Hepatic Dysfunction in Dengue Patients of Western Rural Maharashtra. Med. res. chronicles [Internet]. 2024Jan.19 [cited 2024Feb.23];10(5):261-70. Available from:
Original Research Article