Amyloidosis - A rare case report in Bangladesh

Abstract

Amyloidosis is a disorder where there is extracellular deposition of insoluble protein in different tissues and organs. AL amyloidosis is the commonest type where monoclonal immunoglobin light chain secreted by plasma cells is deposited as amyloid fibrils in tissues which can lead to multiorgan failure. This disorder is a rare and complex condition characterized by the deposition of amyloid proteins in tissues, leading to their dysfunction. The condition may be localized or systemic, with a wide range of clinical manifestations depending on the organs involved, such as the heart, kidneys, liver, gastrointestinal tract, and nervous system. We report a 50-year-old lady with multiple joint pain and multiple papulovesicular lesion around oral cavity, eye, around anus and macroglossia. She was diagnosed as a case of AL amyloidosis by clinical features and skin biopsy. She was put on oral lenalidomide and dexamethasone. This type of papulovesicular lesion is rare form of skin manifestation in AL amyloidosis. The importance of early recognition, multidisciplinary management, and improved healthcare resources in addressing rare diseases like amyloidosis in low-resource settings such as Bangladesh. Awareness campaigns and capacity building in healthcare systems are vital for timely diagnosis and intervention.