ANGIOMYOLIPOMA OF KIDNEY – A CASE REPORT
Abstract
Angiomyolipoma belongs to a family of neoplasms called perivascular epithelioid cell tumors (PEComas). The World Health Organization (WHO) defines PEComas as “mesenchymal tumors composed of histologically, ultrastructurally, and immunohistochemically distinctive perivascular epithelioid cells. Renal angiomyolipoma is an uncommon benign tumor characterized by a variable mixture of adipose tissue, smooth muscle, and thickened blood vessel and perivascular epithelioid cells also known as PEComa. Microscopically, the tumor shows mature adipose tissue, tortuous thick-walled blood vessels lacking elastic tissue lamina, and bundles of smooth muscle that seem to emanate from the vessel wall. A 55-year-old male patient presented with a huge abdominal painful lump in the left hypochondrium. Clinicoradiological evaluation suggests a mass lesion arising from the kidney. Nephrectomy was carried out. The cut section of the kidney showed multiple nodular yellow white and brown areas. Random sections from growth showed an admixture of Spindle cells & adipose tissue along with thick-walled blood vessels. Immunohistochemistry was carried out the result of which showed HMB 45 and Smooth Muscle Actin positive, but cytokeratin was negative. Considering the unilaterality, unifocal, larger size of the tumor and microscopic finding, and IHC result, the case was confirmed as a sporadic angiomyolipoma.
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References
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