MIXED PHENOTYPE ACUTE LEUKEMIA OF T/MYELOID TYPE WITH RARE MULTIPLE CYTOGENETIC ABNORMALITY OF CHROMOSOME 8, 9, 11, 12, 16 AND MARKER CHROMOSOME AND DUAL BLAST POPULATION: A RARE CASE
Keywords:
mixed phenotypic acute leukemia, complex karyotype, therapy
Abstract
Mixed phenotypic acute leukemia (MPAL) represents a very rare and heterogeneous group of acute leukemias comprising 2-5 % of all leukemias. Although WHO 2008 laid down stringent criteria for diagnosis these still pose a diagnostic challenge as It encompasses leukemias having separate populations of blasts of more than one lineage or a single population of blasts which co-express antigens of more than one lineage. Cytogenetics plays a major role not only in diagnosis but also determines the therapy and prognosis. We present a case of far unreported karyotype aberration in this type of acute leukemia 45, XY, -8, del (9)(p21),-11,add(12)(p13),add (16)(p13.3),+mar[20]with therapy-resistant course.
Downloads
Download data is not yet available.
References
1. Borowitz M, Bene MC, Harris NL, Porwit A, Matutes E. Acute leukemias of ambiguous lineage. In: swerdlo SH, Campo E, Harris NL et al, eds. World Health Organisation classification of tumors: Pathology and genetics of tumors of hematopoietic and lymphoid tissues. Lyon, France: IARC Press; 2008:150-155.
2. Chen G, Sands AM, Jianlan S. mixed phenotype acute leukemias. N A J Med Sci. 2012;5(2):119-122
3. Rubnitz JE, Onciu M, Pounds S et al. Acute mixed lineage leukemia in children: the experience of St Jude Children’s Research Hospital. Blood. 2009; 113(21):5083-5089.
4. Matutes E, Pickl WFVan, Veer M, et al. Mixed phenotype acute leukemia (MPAL): clinical and laboratory features and outcome in 100 patients defined according to WHO 2008 classification. Blood. 2011; 117(11):3163-3171.
5. Mitelman, Johansson & Metens, (2011). Mitelman Database of chromosome aberrations and gene fusions in cancer. http://cgap.nci.nih.gov/chromosomes/Mitelman.
6. Moosavi SA, Sanchez J, Adeyinka A, et al. Marker chromosomes are a significant mechanism of high-level RUNX 1 gene amplification in hematological malignancies. Cancer Genet Cytogenet.2009:189(1); 24-8.
7. Petkovic I, Nakic M, Tiefenbach A, et al. marker chromosome 1q in acute lymphocytic leukemia. Cancer Genet Cytogenet.1987:24(2); 251-5.
8. Kawamoto H. a close developmental relationship between the lymphoid and myeloid lineages. Trends Immunol. 2006;27(4):169-175
9. Legrand O, Perrot JY, Simonin G, et al. Adult biphenotypic acute leukemias: an entity with poor prognosis which is related to unfavorable cytogenetics and p-glycoprotein over-expression. Br J Haematol. 1998; 100(1):147-155.
2. Chen G, Sands AM, Jianlan S. mixed phenotype acute leukemias. N A J Med Sci. 2012;5(2):119-122
3. Rubnitz JE, Onciu M, Pounds S et al. Acute mixed lineage leukemia in children: the experience of St Jude Children’s Research Hospital. Blood. 2009; 113(21):5083-5089.
4. Matutes E, Pickl WFVan, Veer M, et al. Mixed phenotype acute leukemia (MPAL): clinical and laboratory features and outcome in 100 patients defined according to WHO 2008 classification. Blood. 2011; 117(11):3163-3171.
5. Mitelman, Johansson & Metens, (2011). Mitelman Database of chromosome aberrations and gene fusions in cancer. http://cgap.nci.nih.gov/chromosomes/Mitelman.
6. Moosavi SA, Sanchez J, Adeyinka A, et al. Marker chromosomes are a significant mechanism of high-level RUNX 1 gene amplification in hematological malignancies. Cancer Genet Cytogenet.2009:189(1); 24-8.
7. Petkovic I, Nakic M, Tiefenbach A, et al. marker chromosome 1q in acute lymphocytic leukemia. Cancer Genet Cytogenet.1987:24(2); 251-5.
8. Kawamoto H. a close developmental relationship between the lymphoid and myeloid lineages. Trends Immunol. 2006;27(4):169-175
9. Legrand O, Perrot JY, Simonin G, et al. Adult biphenotypic acute leukemias: an entity with poor prognosis which is related to unfavorable cytogenetics and p-glycoprotein over-expression. Br J Haematol. 1998; 100(1):147-155.
How to Cite
1.
Rigvardhan R, Kotwal J, Ganguli P, Ahmed R, Sharma A, Singh J. MIXED PHENOTYPE ACUTE LEUKEMIA OF T/MYELOID TYPE WITH RARE MULTIPLE CYTOGENETIC ABNORMALITY OF CHROMOSOME 8, 9, 11, 12, 16 AND MARKER CHROMOSOME AND DUAL BLAST POPULATION: A RARE CASE. Med. res. chronicles [Internet]. 2015May29 [cited 2024Dec.22];2(3):394-8. Available from: https://medrech.com/index.php/medrech/article/view/98
Section
Case Report
