CONGENITAL DYSERYTHROPOIETIC ANEMIA: CASE REPORT OF THREE CASES
Abstract
Congenital dyserythropoietic anemias (CDA) belong to a group of inherited disorders that are characterized by maturation arrest during erythropoiesis and an inappropriate reticulocyte production in contrast with erythroid hyperplasia in the bone marrow. They show specific morphological abnormalities that allowed for morphological classification of these conditions termed CDA type I and II. With advances in genetic analysis, some altered proteins were found to be involved in chromatin assembly, such as codanin 1 in CDA type I and SEC 23B in CDA type II. CDA type III was characterized later with the presence of gigantoblast in the bone marrow. However, even in the absence of genetic analysis, CDAs can be diagnosed if the history of the patient, clinical examination, and profile is taken into account and a high index of suspicion is maintained if specific morphological abnormalities are found in the bone marrow and peripheral blood.
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References
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