Recurrent anti-GAD65 limbic encephalitis in a pediatric patient
Abstract
Limbic encephalitis (LE) associated with anti-glutamic acid decarboxylase (GAD) 65 antibodies is an autoimmune condition characterized by signs and symptoms of limbic system inflammation. Herein we present the case of an 8-year-old girl with recurrent anti-GAD65 limbic encephalitis with a past history of viral infection.
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References
Finelli, P. F. (2011). Autoimmune Limbic Encephalitis With GAD Antibodies. The Neurohospitalist, 1(4), 178–181.
Vianello, M., Tavolato, B., & Giometto, B. (2002). Glutamic acid decarboxylase autoantibodies and neurological disorders. Neurological Sciences, 23(4), 145–151.
Dade, M., Berzero, G., Izquierdo, C., Giry, M., Benazra, M., Delattre, J. Y., Psimaras, D., & Alentorn, A. (2020). Neurological Syndromes Associated with Anti-GAD Antibodies. International Journal of Molecular Sciences, 21(10), 3701.
Lancaster, E., & Dalmau, J. (2012). Neuronal autoantigens—pathogenesis, associated disorders and antibody testing. Nature Reviews Neurology, 8(7), 380–390.
Hacohen, Y., Wright, S., Waters, P., Agrawal, S., Carr, L., Cross, H., de Sousa, C., DeVile, C., Fallon, P., Gupta, R., Hedderly, T., Hughes, E., Kerr, T., Lascelles, K., Lin, J. P., Philip, S., Pohl, K., Prabahkar, P., Smith, M., . . . Lim, M. J. (2012). Paediatric autoimmune encephalopathies: clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigens. Journal of Neurology, Neurosurgery & Psychiatry, 84(7), 748–755.
Armangue, T., Petit-Pedrol, M., & Dalmau, J. (2012). Autoimmune Encephalitis in Children. Journal of Child Neurology, 27(11), 1460–1469.
Thieben, M. J., Lennon, V. A., Boeve, B. F., Aksamit, A. J., Keegan, M., & Vernino, S. (2004). Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody. Neurology, 62(7), 1177–1182.
Hermetter, C., Fazekas, F., & Hochmeister, S. (2018). Systematic Review: Syndromes, Early Diagnosis, and Treatment in Autoimmune Encephalitis. Frontiers in Neurology, 9.
Bushati, A., Aleksi, K., Tako, A., & Shehu, A. (2022). Neurological Complications with Delayed Onset in Post-COVID-19 Pediatric Patients. International Journal of Science and Research (IJSR), 11(4), 691–695.
Haberlandt, E., Bast, T., Ebner, A., Holthausen, H., Kluger, G., Kravljanac, R., Kroll-Seger, J., Kurlemann, G., Makowski, C., Rostasy, K., Tuschen-Hofstatter, E., Weber, G., Vincent, A., & Bien, C. (2010). Limbic encephalitis in children and adolescents. Archives of Disease in Childhood, 96(2), 186–191.
Gagnon, M. M., & Savard, M. (2016). Limbic Encephalitis Associated With GAD65 Antibodies: Brief Review of the Relevant literature. Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques, 43(4), 486–493.
Bien, C. G., & Bien, C. I. (2020c). Autoimmune encephalitis in children and adolescents. Neurological Research and Practice, 2(1).
Olivieri, G., Contaldo, I., Ferrantini, G., Musto, E., Scalise, R., Stefanini, M. C., Battaglia, D., & Mercuri, E. (2016). Autoimmune encephalopathies in children: diagnostic clues and therapeutic challenges. Neuroimmunology and Neuroinflammation, 3(7), 147.
Smets, I., & Titulaer, M. J. (2022). Antibody Therapies in Autoimmune Encephalitis. Neurotherapeutics.
Yang, J., & Liu, X. (2021). Immunotherapy for Refractory Autoimmune Encephalitis. Frontiers in Immunology, 12.
